In vivo characterization of sAC null sperm

In vivo characterization of sAC null sperm

Targeted disruption of the soluble adenylyl cyclase (ADCY10; sAC) gene results in male-specific sterility without affecting spermatogenesis, mating behavior, or spermatozoa morphology and count; however, it dramatically impairs sperm motility and prevents capacitation. These phenotypes were identifi...

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Bibliographic Details
Main Authors: Carla Ritagliati, Sylvia Ayoub, Melanie Balbach, Jochen Buck, Lonny R. Levin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
in vivo migration
motility
soluble adenylyl cyclase
hyperactivation
acrosome reaction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1134051/full

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