Selecting Optimal Proton Pencil Beam Scanning Plan Parameters to Reduce Dose Discrepancy between Discrete Spot Plan and Continuous Scanning: A Proof-of-Concept Study
Pencil beam scanning delivered with continuous scanning has several advantages over conventional discrete spot scanning. Such advantages include improved beam delivery efficiency and reduced beam delivery time. However, a move dose is delivered between consecutive spots with continuous scanning, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/16/4084 |
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| author | Xiaoying Liang Chris J. Beltran Chunbo Liu Chunjoo Park Bo Lu Sridhar Yaddanapudi Jun Tan Keith M. Furutani |
| author_facet | Xiaoying Liang Chris J. Beltran Chunbo Liu Chunjoo Park Bo Lu Sridhar Yaddanapudi Jun Tan Keith M. Furutani |
| author_sort | Xiaoying Liang |
| collection | DOAJ |
| description | Pencil beam scanning delivered with continuous scanning has several advantages over conventional discrete spot scanning. Such advantages include improved beam delivery efficiency and reduced beam delivery time. However, a move dose is delivered between consecutive spots with continuous scanning, and current treatment planning systems do not take this into account. Therefore, continuous scanning and discrete spot plans have an inherent dose discrepancy. Using the operating parameters of the state-of-the-art particle therapy system, we conducted a proof-of-concept study in which we systematically generated 28 plans for cubic targets with different combinations of plan parameters and simulated the dose discrepancies between continuous scanning and a planned one. A nomograph to guide the selection of plan parameters was developed to reduce the dose discrepancy. The effectiveness of the nomograph was evaluated with two clinical cases (one prostate and one liver). Plans with parameters guided by the nomograph decreased dose discrepancy than those used standard plan parameters. Specifically, the 2%/2 mm gamma passing rate increased from 96.3% to 100% for the prostate case and from 97.8% to 99.7% for the liver case. The CTV DVH root mean square error decreased from 2.2% to 0.2% for the prostate case and from 1.8% to 0.9% for the liver case. The decreased dose discrepancy may allow the relaxing of the delivery constraint for some cases, leading to greater benefits in continuous scanning. Further investigation is warranted. |
| first_indexed | 2024-03-11T00:03:23Z |
| format | Article |
| id | doaj.art-75054fdd3aae4541afdb3250a42a5ecb |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:03:23Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-75054fdd3aae4541afdb3250a42a5ecb2023-11-19T00:32:59ZengMDPI AGCancers2072-66942023-08-011516408410.3390/cancers15164084Selecting Optimal Proton Pencil Beam Scanning Plan Parameters to Reduce Dose Discrepancy between Discrete Spot Plan and Continuous Scanning: A Proof-of-Concept StudyXiaoying Liang0Chris J. Beltran1Chunbo Liu2Chunjoo Park3Bo Lu4Sridhar Yaddanapudi5Jun Tan6Keith M. Furutani7Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Radiation Oncology, Mayo Clinic, Jacksonville, FL 32224, USAPencil beam scanning delivered with continuous scanning has several advantages over conventional discrete spot scanning. Such advantages include improved beam delivery efficiency and reduced beam delivery time. However, a move dose is delivered between consecutive spots with continuous scanning, and current treatment planning systems do not take this into account. Therefore, continuous scanning and discrete spot plans have an inherent dose discrepancy. Using the operating parameters of the state-of-the-art particle therapy system, we conducted a proof-of-concept study in which we systematically generated 28 plans for cubic targets with different combinations of plan parameters and simulated the dose discrepancies between continuous scanning and a planned one. A nomograph to guide the selection of plan parameters was developed to reduce the dose discrepancy. The effectiveness of the nomograph was evaluated with two clinical cases (one prostate and one liver). Plans with parameters guided by the nomograph decreased dose discrepancy than those used standard plan parameters. Specifically, the 2%/2 mm gamma passing rate increased from 96.3% to 100% for the prostate case and from 97.8% to 99.7% for the liver case. The CTV DVH root mean square error decreased from 2.2% to 0.2% for the prostate case and from 1.8% to 0.9% for the liver case. The decreased dose discrepancy may allow the relaxing of the delivery constraint for some cases, leading to greater benefits in continuous scanning. Further investigation is warranted.https://www.mdpi.com/2072-6694/15/16/4084radiation oncologyparticle therapypencil beam scanningcontinuous scanningplan parameters |
| spellingShingle | Xiaoying Liang Chris J. Beltran Chunbo Liu Chunjoo Park Bo Lu Sridhar Yaddanapudi Jun Tan Keith M. Furutani Selecting Optimal Proton Pencil Beam Scanning Plan Parameters to Reduce Dose Discrepancy between Discrete Spot Plan and Continuous Scanning: A Proof-of-Concept Study Cancers radiation oncology particle therapy pencil beam scanning continuous scanning plan parameters |
| title | Selecting Optimal Proton Pencil Beam Scanning Plan Parameters to Reduce Dose Discrepancy between Discrete Spot Plan and Continuous Scanning: A Proof-of-Concept Study |
| title_full | Selecting Optimal Proton Pencil Beam Scanning Plan Parameters to Reduce Dose Discrepancy between Discrete Spot Plan and Continuous Scanning: A Proof-of-Concept Study |
| title_fullStr | Selecting Optimal Proton Pencil Beam Scanning Plan Parameters to Reduce Dose Discrepancy between Discrete Spot Plan and Continuous Scanning: A Proof-of-Concept Study |
| title_full_unstemmed | Selecting Optimal Proton Pencil Beam Scanning Plan Parameters to Reduce Dose Discrepancy between Discrete Spot Plan and Continuous Scanning: A Proof-of-Concept Study |
| title_short | Selecting Optimal Proton Pencil Beam Scanning Plan Parameters to Reduce Dose Discrepancy between Discrete Spot Plan and Continuous Scanning: A Proof-of-Concept Study |
| title_sort | selecting optimal proton pencil beam scanning plan parameters to reduce dose discrepancy between discrete spot plan and continuous scanning a proof of concept study |
| topic | radiation oncology particle therapy pencil beam scanning continuous scanning plan parameters |
| url | https://www.mdpi.com/2072-6694/15/16/4084 |
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