| Summary: | An in-depth review was presented on improving the quality of wastewater through organic matter indicators. The aim was to formulate a new sequential treatment method from toxic to stable levels to increase the efficiency of detoxification and stabilization of organic matter. Literature collection was compiled from the Mendeley Reference Manager tool with the search phrase: biochemical oxygen demand, chemical oxygen demand, detoxification, biodegradation, stabilization. Several screening criteria were applied to obtain the selected documentation for this study. Results revealed that there was an increase in the detoxification of untreated wastewater, which can be shown by increasing the ratio of biochemical oxygen demand/chemical oxygen demand. This could be treated subsequently to reduce the ratio into stable organic matter that can be safely disposed of into the environment. Toxicity and respiration tests were used to assess the feasibility of the treatment system, and for monitoring processes during operation and maintenance of treatments.
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