Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage
Heparan sulfate is a highly sulfated polysaccharide abundant on the surface of hepatocytes and surrounding extracellular matrix. Emerging evidence demonstrates that heparan sulfate plays an important role in neutralizing the activities of proinflammatory damage associate molecular patterns (DAMPs) t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/11/503 |
| _version_ | 1797547769544572928 |
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| author | Katelyn Arnold Yi-En Liao Jian Liu |
| author_facet | Katelyn Arnold Yi-En Liao Jian Liu |
| author_sort | Katelyn Arnold |
| collection | DOAJ |
| description | Heparan sulfate is a highly sulfated polysaccharide abundant on the surface of hepatocytes and surrounding extracellular matrix. Emerging evidence demonstrates that heparan sulfate plays an important role in neutralizing the activities of proinflammatory damage associate molecular patterns (DAMPs) that are released from hepatocytes under pathological conditions. Unlike proteins and nucleic acids, isolation of homogenous heparan sulfate polysaccharides from biological sources is not possible, adding difficulty to study the functional role of heparan sulfate. Recent advancement in the development of a chemoenzymatic approach allows production of a large number of structurally defined oligosaccharides. These oligosaccharides are used to probe the physiological functions of heparan sulfate in liver damage under different pathological conditions. The findings provide a potential new therapeutic agent to treat liver diseases that are associated with excessive inflammation. |
| first_indexed | 2024-03-10T14:49:49Z |
| format | Article |
| id | doaj.art-75096315c0f147d28797eabc1eff5264 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T14:49:49Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-75096315c0f147d28797eabc1eff52642023-11-20T21:05:34ZengMDPI AGBiomedicines2227-90592020-11-0181150310.3390/biomedicines8110503Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver DamageKatelyn Arnold0Yi-En Liao1Jian Liu2Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USADivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USADivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USAHeparan sulfate is a highly sulfated polysaccharide abundant on the surface of hepatocytes and surrounding extracellular matrix. Emerging evidence demonstrates that heparan sulfate plays an important role in neutralizing the activities of proinflammatory damage associate molecular patterns (DAMPs) that are released from hepatocytes under pathological conditions. Unlike proteins and nucleic acids, isolation of homogenous heparan sulfate polysaccharides from biological sources is not possible, adding difficulty to study the functional role of heparan sulfate. Recent advancement in the development of a chemoenzymatic approach allows production of a large number of structurally defined oligosaccharides. These oligosaccharides are used to probe the physiological functions of heparan sulfate in liver damage under different pathological conditions. The findings provide a potential new therapeutic agent to treat liver diseases that are associated with excessive inflammation.https://www.mdpi.com/2227-9059/8/11/503heparan sulfatechemoenzymatic synthesisoligosaccharidesDAMPSinflammation |
| spellingShingle | Katelyn Arnold Yi-En Liao Jian Liu Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage Biomedicines heparan sulfate chemoenzymatic synthesis oligosaccharides DAMPS inflammation |
| title | Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage |
| title_full | Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage |
| title_fullStr | Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage |
| title_full_unstemmed | Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage |
| title_short | Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage |
| title_sort | potential use of anti inflammatory synthetic heparan sulfate to attenuate liver damage |
| topic | heparan sulfate chemoenzymatic synthesis oligosaccharides DAMPS inflammation |
| url | https://www.mdpi.com/2227-9059/8/11/503 |
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