A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products
Coping with a zero-waste, more sustainable economy represents the biggest challenge for food market nowadays. We have previously demonstrated that by applying smart multidisciplinary waste management strategies to purple sea urchin (<i>Paracentrotus lividus</i>) food waste, it is possibl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/9/1730 |
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| author | Luca Melotti Andrea Venerando Giulia Zivelonghi Anna Carolo Stefania Marzorati Giordana Martinelli Michela Sugni Lisa Maccatrozzo Marco Patruno |
| author_facet | Luca Melotti Andrea Venerando Giulia Zivelonghi Anna Carolo Stefania Marzorati Giordana Martinelli Michela Sugni Lisa Maccatrozzo Marco Patruno |
| author_sort | Luca Melotti |
| collection | DOAJ |
| description | Coping with a zero-waste, more sustainable economy represents the biggest challenge for food market nowadays. We have previously demonstrated that by applying smart multidisciplinary waste management strategies to purple sea urchin (<i>Paracentrotus lividus</i>) food waste, it is possible to obtain both a high biocompatible collagen to produce novel skin substitutes and potent antioxidant pigments, namely polyhydroxynapthoquinones (PHNQs). Herein, we have analyzed the biological activities of the PHNQs extract, composed of Spinochrome A and B, on human skin fibroblast cells to explore their future applicability in the treatment of non-healing skin wounds with the objective of overcoming the excessive oxidative stress that hinders wound tissue regeneration. Our results clearly demonstrate that the antioxidant activity of PHNQs is not restricted to their ability to scavenge reactive oxygen species; rather, it can be traced back to an upregulating effect on the expression of superoxide dismutase 1, one of the major components of the endogenous antioxidant enzymes defense system. In addition, the PHNQs extract, in combination with Antimycin A, displayed a synergistic pro-apoptotic effect, envisaging its possible employment against chemoresistance in cancer treatments. Overall, this study highlights the validity of a zero-waste approach in the seafood chain to obtain high-value products, which, in turn, may be exploited for different biomedical applications. |
| first_indexed | 2024-03-10T23:06:30Z |
| format | Article |
| id | doaj.art-750b5be051d8491da80e32d7b2ce37f2 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T23:06:30Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-750b5be051d8491da80e32d7b2ce37f22023-11-19T09:19:37ZengMDPI AGAntioxidants2076-39212023-09-01129173010.3390/antiox12091730A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-ProductsLuca Melotti0Andrea Venerando1Giulia Zivelonghi2Anna Carolo3Stefania Marzorati4Giordana Martinelli5Michela Sugni6Lisa Maccatrozzo7Marco Patruno8Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell’Università 16, 35020 Padova, ItalyDepartment of Agricultural, Food, Environmental and Animal Sciences, University of Udine, Via delle Scienze 206, 33100 Udine, ItalyDepartment of Comparative Biomedicine and Food Science, University of Padua, Viale dell’Università 16, 35020 Padova, ItalyDepartment of Comparative Biomedicine and Food Science, University of Padua, Viale dell’Università 16, 35020 Padova, ItalyDepartment of Environmental Science and Policy, University of Milan, Via Celoria 2, 20133 Milan, ItalyDepartment of Environmental Science and Policy, University of Milan, Via Celoria 2, 20133 Milan, ItalyDepartment of Environmental Science and Policy, University of Milan, Via Celoria 2, 20133 Milan, ItalyDepartment of Comparative Biomedicine and Food Science, University of Padua, Viale dell’Università 16, 35020 Padova, ItalyDepartment of Comparative Biomedicine and Food Science, University of Padua, Viale dell’Università 16, 35020 Padova, ItalyCoping with a zero-waste, more sustainable economy represents the biggest challenge for food market nowadays. We have previously demonstrated that by applying smart multidisciplinary waste management strategies to purple sea urchin (<i>Paracentrotus lividus</i>) food waste, it is possible to obtain both a high biocompatible collagen to produce novel skin substitutes and potent antioxidant pigments, namely polyhydroxynapthoquinones (PHNQs). Herein, we have analyzed the biological activities of the PHNQs extract, composed of Spinochrome A and B, on human skin fibroblast cells to explore their future applicability in the treatment of non-healing skin wounds with the objective of overcoming the excessive oxidative stress that hinders wound tissue regeneration. Our results clearly demonstrate that the antioxidant activity of PHNQs is not restricted to their ability to scavenge reactive oxygen species; rather, it can be traced back to an upregulating effect on the expression of superoxide dismutase 1, one of the major components of the endogenous antioxidant enzymes defense system. In addition, the PHNQs extract, in combination with Antimycin A, displayed a synergistic pro-apoptotic effect, envisaging its possible employment against chemoresistance in cancer treatments. Overall, this study highlights the validity of a zero-waste approach in the seafood chain to obtain high-value products, which, in turn, may be exploited for different biomedical applications.https://www.mdpi.com/2076-3921/12/9/1730polyhydroxynaphtoquinonesspinochromessea urchinantioxidantmarine food wastezero-waste approach |
| spellingShingle | Luca Melotti Andrea Venerando Giulia Zivelonghi Anna Carolo Stefania Marzorati Giordana Martinelli Michela Sugni Lisa Maccatrozzo Marco Patruno A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products Antioxidants polyhydroxynaphtoquinones spinochromes sea urchin antioxidant marine food waste zero-waste approach |
| title | A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products |
| title_full | A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products |
| title_fullStr | A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products |
| title_full_unstemmed | A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products |
| title_short | A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products |
| title_sort | second life for seafood waste therapeutical promises of polyhydroxynapthoquinones extracted from sea urchin by products |
| topic | polyhydroxynaphtoquinones spinochromes sea urchin antioxidant marine food waste zero-waste approach |
| url | https://www.mdpi.com/2076-3921/12/9/1730 |
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