Mortality in US veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factors
Pulmonary hypertension (PH) occurs when the pulmonary vasculature is itself diseased or becomes affected secondarily by comorbid conditions, commonly left heart or lung disease. The high prevalence of chronic cardiopulmonary conditions among patients served by Veterans Health Administration (VHA) su...
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| Format: | Article |
| Language: | English |
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Wiley
2019-02-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045894019825763 |
| _version_ | 1811328143872491520 |
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| author | Aaron W. Trammell Amit J. Shah Lawrence S. Phillips C. Michael Hart |
| author_facet | Aaron W. Trammell Amit J. Shah Lawrence S. Phillips C. Michael Hart |
| author_sort | Aaron W. Trammell |
| collection | DOAJ |
| description | Pulmonary hypertension (PH) occurs when the pulmonary vasculature is itself diseased or becomes affected secondarily by comorbid conditions, commonly left heart or lung disease. The high prevalence of chronic cardiopulmonary conditions among patients served by Veterans Health Administration (VHA) suggests this population may be particularly susceptible to PH. We sought to identify clinical features and outcomes in veterans diagnosed with PH. We utilized the VHA Corporate Data Warehouse to identify veterans diagnosed between January 1, 2003 and September 30, 2015, assess relevant patient characteristics and their survival time. The effects of PH subtype and baseline factors on outcome were estimated by Cox modeling. There were 110,564 veterans diagnosed with PH during the study period. These veterans were predominantly male, had median age 70.2, and had a high burden of comorbid conditions. PH was frequently due to left heart and/or lung disease. Average survival after PH diagnosis was 3.88 years. Compared with other types, PH due to left heart disease, lung disease or both had shorter survival. This large retrospective study of veterans demonstrates the significance of PH due to left heart and/or lung disease which was common and had high risk of death. Multi-comorbidity was common and added to risk. These findings underscore the need for risk assessment tools for subjects with non-Group 1 PH and novel management strategies to improve their outcome. This study details the largest retrospective cohort assembled for evaluation of secondary PH and allows hypothesis-generating inquiries into these common conditions that are rarely prospectively studied. |
| first_indexed | 2024-04-13T15:20:04Z |
| format | Article |
| id | doaj.art-750b734cade54e049285d3c86f2c4be5 |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-04-13T15:20:04Z |
| publishDate | 2019-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-750b734cade54e049285d3c86f2c4be52022-12-22T02:41:41ZengWileyPulmonary Circulation2045-89402019-02-01910.1177/2045894019825763Mortality in US veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factorsAaron W. Trammell0Amit J. Shah1Lawrence S. Phillips2C. Michael Hart3Atlanta VA Medical Center, Decatur, Georgia, USADepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USADivision of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USAAtlanta VA Medical Center, Decatur, Georgia, USAPulmonary hypertension (PH) occurs when the pulmonary vasculature is itself diseased or becomes affected secondarily by comorbid conditions, commonly left heart or lung disease. The high prevalence of chronic cardiopulmonary conditions among patients served by Veterans Health Administration (VHA) suggests this population may be particularly susceptible to PH. We sought to identify clinical features and outcomes in veterans diagnosed with PH. We utilized the VHA Corporate Data Warehouse to identify veterans diagnosed between January 1, 2003 and September 30, 2015, assess relevant patient characteristics and their survival time. The effects of PH subtype and baseline factors on outcome were estimated by Cox modeling. There were 110,564 veterans diagnosed with PH during the study period. These veterans were predominantly male, had median age 70.2, and had a high burden of comorbid conditions. PH was frequently due to left heart and/or lung disease. Average survival after PH diagnosis was 3.88 years. Compared with other types, PH due to left heart disease, lung disease or both had shorter survival. This large retrospective study of veterans demonstrates the significance of PH due to left heart and/or lung disease which was common and had high risk of death. Multi-comorbidity was common and added to risk. These findings underscore the need for risk assessment tools for subjects with non-Group 1 PH and novel management strategies to improve their outcome. This study details the largest retrospective cohort assembled for evaluation of secondary PH and allows hypothesis-generating inquiries into these common conditions that are rarely prospectively studied.https://doi.org/10.1177/2045894019825763 |
| spellingShingle | Aaron W. Trammell Amit J. Shah Lawrence S. Phillips C. Michael Hart Mortality in US veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factors Pulmonary Circulation |
| title | Mortality in US veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factors |
| title_full | Mortality in US veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factors |
| title_fullStr | Mortality in US veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factors |
| title_full_unstemmed | Mortality in US veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factors |
| title_short | Mortality in US veterans with pulmonary hypertension: a retrospective analysis of survival by subtype and baseline factors |
| title_sort | mortality in us veterans with pulmonary hypertension a retrospective analysis of survival by subtype and baseline factors |
| url | https://doi.org/10.1177/2045894019825763 |
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