Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder
Physical as well as cognitive training interventions improve specific cognitive functions but effects barely generalize on global cognition. Combined physical and cognitive training may overcome this shortcoming as physical training may facilitate the neuroplastic potential which, in turn, may be gu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-08-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00152/full |
| _version_ | 1811344996609032192 |
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| author | Panagiotis D. Bamidis Patrick eFissler Sokratis G. Papageorgiou Vasiliki eZilidou Evdokimos I. Konstantinidis Antonis S. Billis Evangelia eRomanopoulou Maria eKaragianni Maria eKaragianni Ion eBearatis Angeliki eTsapanou Georgia eTsilikopoulou Eirini eGrigoriadou Eirini eGrigoriadou Aristea eLadas Aristea eLadas Athina eKyrillidou Athina eKyrillidou Anthoula eTsolaki Anthoula eTsolaki Christos eFrantzidis Efstathios eSidiropoulos Anastasios eSiountas Stavroula eMatsi John ePapatriantafyllou Eleni eMargioti Aspasia eNika Winfried eSchlee Thomas eElbert Magda eTsolaki Magda eTsolaki Ana B. Vivas Iris-Tatjana eKolassa |
| author_facet | Panagiotis D. Bamidis Patrick eFissler Sokratis G. Papageorgiou Vasiliki eZilidou Evdokimos I. Konstantinidis Antonis S. Billis Evangelia eRomanopoulou Maria eKaragianni Maria eKaragianni Ion eBearatis Angeliki eTsapanou Georgia eTsilikopoulou Eirini eGrigoriadou Eirini eGrigoriadou Aristea eLadas Aristea eLadas Athina eKyrillidou Athina eKyrillidou Anthoula eTsolaki Anthoula eTsolaki Christos eFrantzidis Efstathios eSidiropoulos Anastasios eSiountas Stavroula eMatsi John ePapatriantafyllou Eleni eMargioti Aspasia eNika Winfried eSchlee Thomas eElbert Magda eTsolaki Magda eTsolaki Ana B. Vivas Iris-Tatjana eKolassa |
| author_sort | Panagiotis D. Bamidis |
| collection | DOAJ |
| description | Physical as well as cognitive training interventions improve specific cognitive functions but effects barely generalize on global cognition. Combined physical and cognitive training may overcome this shortcoming as physical training may facilitate the neuroplastic potential which, in turn, may be guided by cognitive training. This study aimed at investigating the benefits of combined training on global cognition while assessing the effect of training dosage and exploring the role of several potential effect modifiers. In this multi-center study, 322 older adults with or without neurocognitive disorders were allocated to a computerized, game-based, combined physical and cognitive training group (n = 237) or a passive control group (n = 85). Training group participants were allocated to different training dosages ranging from 24 to 110 potential sessions. In a pre-posttest design, global cognition was assessed by averaging standardized performance in working memory, episodic memory and executive function tests. The intervention group increased in global cognition compared to the control group, p = .002, Cohen’s d = 0.31. Exploratory analysis revealed a trend for less benefits in participants with more severe neurocognitive disorder, p = .08 (cognitively healthy: d = 0.54; mild cognitive impairment: d = 0.19; dementia: d = 0.04). In participants without dementia, we found a dose-response effect of the potential number and of the completed number of training sessions on global cognition, p = .008 and p = .04, respectively. The results indicate that combined physical and cognitive training improves global cognition in a dose-responsive manner but these benefits may be less pronounced in older adults with more severe neurocognitive disorder. The long-lasting impact of combined training on the incidence and trajectory of neurocognitive disorders in relation to its severity should be assessed in future long-term trials. |
| first_indexed | 2024-04-13T19:56:29Z |
| format | Article |
| id | doaj.art-750bd03bbed542c6b3a7f420a5bbcfd0 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T19:56:29Z |
| publishDate | 2015-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-750bd03bbed542c6b3a7f420a5bbcfd02022-12-22T02:32:19ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-08-01710.3389/fnagi.2015.00152133920Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorderPanagiotis D. Bamidis0Patrick eFissler1Sokratis G. Papageorgiou2Vasiliki eZilidou3Evdokimos I. Konstantinidis4Antonis S. Billis5Evangelia eRomanopoulou6Maria eKaragianni7Maria eKaragianni8Ion eBearatis9Angeliki eTsapanou10Georgia eTsilikopoulou11Eirini eGrigoriadou12Eirini eGrigoriadou13Aristea eLadas14Aristea eLadas15Athina eKyrillidou16Athina eKyrillidou17Anthoula eTsolaki18Anthoula eTsolaki19Christos eFrantzidis20Efstathios eSidiropoulos21Anastasios eSiountas22Stavroula eMatsi23John ePapatriantafyllou24Eleni eMargioti25Aspasia eNika26Winfried eSchlee27Thomas eElbert28Magda eTsolaki29Magda eTsolaki30Ana B. Vivas31Iris-Tatjana eKolassa32Aristotle University of ThessalonikiUniversity of UlmNational Kapodistrian University of AthensAristotle University of ThessalonikiAristotle University of ThessalonikiAristotle University of ThessalonikiAristotle University of ThessalonikiAristotle University of ThessalonikiGreek Association of Alzheimer’s Disease and Related DisordersNational Kapodistrian University of AthensNational Kapodistrian University of AthensNational Kapodistrian University of AthensAristotle University of ThessalonikiGreek Association of Alzheimer’s Disease and Related DisordersAristotle University of ThessalonikiThe University of Sheffield International Faculty, City CollegeAristotle University of ThessalonikiGreek Association of Alzheimer’s Disease and Related DisordersAristotle University of ThessalonikiGreek Association of Alzheimer’s Disease and Related DisordersAristotle University of ThessalonikiAristotle University of ThessalonikiAristotle University of ThessalonikiNational Kapodistrian University of AthensNational Kapodistrian University of AthensNational Kapodistrian University of AthensNational Kapodistrian University of AthensUniversity of RegensburgUniversity of KonstanzGreek Association of Alzheimer’s Disease and Related DisordersAristotle University of ThessalonikiThe University of Sheffield International Faculty, City CollegeUniversity of UlmPhysical as well as cognitive training interventions improve specific cognitive functions but effects barely generalize on global cognition. Combined physical and cognitive training may overcome this shortcoming as physical training may facilitate the neuroplastic potential which, in turn, may be guided by cognitive training. This study aimed at investigating the benefits of combined training on global cognition while assessing the effect of training dosage and exploring the role of several potential effect modifiers. In this multi-center study, 322 older adults with or without neurocognitive disorders were allocated to a computerized, game-based, combined physical and cognitive training group (n = 237) or a passive control group (n = 85). Training group participants were allocated to different training dosages ranging from 24 to 110 potential sessions. In a pre-posttest design, global cognition was assessed by averaging standardized performance in working memory, episodic memory and executive function tests. The intervention group increased in global cognition compared to the control group, p = .002, Cohen’s d = 0.31. Exploratory analysis revealed a trend for less benefits in participants with more severe neurocognitive disorder, p = .08 (cognitively healthy: d = 0.54; mild cognitive impairment: d = 0.19; dementia: d = 0.04). In participants without dementia, we found a dose-response effect of the potential number and of the completed number of training sessions on global cognition, p = .008 and p = .04, respectively. The results indicate that combined physical and cognitive training improves global cognition in a dose-responsive manner but these benefits may be less pronounced in older adults with more severe neurocognitive disorder. The long-lasting impact of combined training on the incidence and trajectory of neurocognitive disorders in relation to its severity should be assessed in future long-term trials.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00152/fullAgingDementiaMild Cognitive Impairmentcognitive trainingphysical trainingbrain fitness |
| spellingShingle | Panagiotis D. Bamidis Patrick eFissler Sokratis G. Papageorgiou Vasiliki eZilidou Evdokimos I. Konstantinidis Antonis S. Billis Evangelia eRomanopoulou Maria eKaragianni Maria eKaragianni Ion eBearatis Angeliki eTsapanou Georgia eTsilikopoulou Eirini eGrigoriadou Eirini eGrigoriadou Aristea eLadas Aristea eLadas Athina eKyrillidou Athina eKyrillidou Anthoula eTsolaki Anthoula eTsolaki Christos eFrantzidis Efstathios eSidiropoulos Anastasios eSiountas Stavroula eMatsi John ePapatriantafyllou Eleni eMargioti Aspasia eNika Winfried eSchlee Thomas eElbert Magda eTsolaki Magda eTsolaki Ana B. Vivas Iris-Tatjana eKolassa Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder Frontiers in Aging Neuroscience Aging Dementia Mild Cognitive Impairment cognitive training physical training brain fitness |
| title | Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder |
| title_full | Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder |
| title_fullStr | Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder |
| title_full_unstemmed | Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder |
| title_short | Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder |
| title_sort | gains in cognition through combined cognitive and physical training the role of training dosage and severity of neurocognitive disorder |
| topic | Aging Dementia Mild Cognitive Impairment cognitive training physical training brain fitness |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00152/full |
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