Improvements in Systemic Therapies for Advanced Malignant Mesothelioma
Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy associated with poor prognosis and a 5-year survival rate of 12%. Many drugs have been tested over the years with conflicting results. The aim of this review is to provide an overview of current therapies in MPM and how to best...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/13/10415 |
| _version_ | 1797591634544689152 |
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| author | Chiara Deiana Francesca Fabbri Simona Tavolari Andrea Palloni Giovanni Brandi |
| author_facet | Chiara Deiana Francesca Fabbri Simona Tavolari Andrea Palloni Giovanni Brandi |
| author_sort | Chiara Deiana |
| collection | DOAJ |
| description | Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy associated with poor prognosis and a 5-year survival rate of 12%. Many drugs have been tested over the years with conflicting results. The aim of this review is to provide an overview of current therapies in MPM and how to best interpret the data available on these drugs. Furthermore, we focused on promising treatments under investigation, such as immunotherapy with targets different from anti-PD-1/PD-L1 inhibitors, vaccines, target therapies, and metabolism-based strategies. |
| first_indexed | 2024-03-11T01:40:05Z |
| format | Article |
| id | doaj.art-750ce89a06b74d45af63641dd4298ac9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:40:05Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-750ce89a06b74d45af63641dd4298ac92023-11-18T16:37:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124131041510.3390/ijms241310415Improvements in Systemic Therapies for Advanced Malignant MesotheliomaChiara Deiana0Francesca Fabbri1Simona Tavolari2Andrea Palloni3Giovanni Brandi4Medical Oncology, IRCCS Azienda Ospedaliera, Universitaria di Bologna, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliera, Universitaria di Bologna, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliera, Universitaria di Bologna, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliera, Universitaria di Bologna, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliera, Universitaria di Bologna, 40138 Bologna, ItalyMalignant pleural mesothelioma (MPM) is a rare and aggressive malignancy associated with poor prognosis and a 5-year survival rate of 12%. Many drugs have been tested over the years with conflicting results. The aim of this review is to provide an overview of current therapies in MPM and how to best interpret the data available on these drugs. Furthermore, we focused on promising treatments under investigation, such as immunotherapy with targets different from anti-PD-1/PD-L1 inhibitors, vaccines, target therapies, and metabolism-based strategies.https://www.mdpi.com/1422-0067/24/13/10415mesotheliomaadvanced mesotheliomasystemic therapiesnovel approachesimmunotherapytarget therapy |
| spellingShingle | Chiara Deiana Francesca Fabbri Simona Tavolari Andrea Palloni Giovanni Brandi Improvements in Systemic Therapies for Advanced Malignant Mesothelioma International Journal of Molecular Sciences mesothelioma advanced mesothelioma systemic therapies novel approaches immunotherapy target therapy |
| title | Improvements in Systemic Therapies for Advanced Malignant Mesothelioma |
| title_full | Improvements in Systemic Therapies for Advanced Malignant Mesothelioma |
| title_fullStr | Improvements in Systemic Therapies for Advanced Malignant Mesothelioma |
| title_full_unstemmed | Improvements in Systemic Therapies for Advanced Malignant Mesothelioma |
| title_short | Improvements in Systemic Therapies for Advanced Malignant Mesothelioma |
| title_sort | improvements in systemic therapies for advanced malignant mesothelioma |
| topic | mesothelioma advanced mesothelioma systemic therapies novel approaches immunotherapy target therapy |
| url | https://www.mdpi.com/1422-0067/24/13/10415 |
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