Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China
Background To systematically explore the risk factors of cutaneous warts and influence factor for the effectiveness of 5-fluorouracil (5-FU). Methods This is a case-control study of 408 cutaneous warts patients and 408 controls of Chinese Han population in southern China. In addition, 244 patients w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-04-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2019.1654073 |
| _version_ | 1797683615103975424 |
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| author | Zhi P. Xiao Que P. Liu Hong F. Xie Ji Li Ming L. Chen Dan Jian |
| author_facet | Zhi P. Xiao Que P. Liu Hong F. Xie Ji Li Ming L. Chen Dan Jian |
| author_sort | Zhi P. Xiao |
| collection | DOAJ |
| description | Background To systematically explore the risk factors of cutaneous warts and influence factor for the effectiveness of 5-fluorouracil (5-FU). Methods This is a case-control study of 408 cutaneous warts patients and 408 controls of Chinese Han population in southern China. In addition, 244 patients who presented with an initial episode of warts without treatment were treated with intralesional 5-FU. The influence factors of 5-FU therapeutic effects were analyzed. Results After adjustment, we found age (≤14 years old), lower education attainment, alcohol intake, smoking, less daily sleeping hours, severe psychological stress, hyperhidrosis, living in house or apartment, having cutaneous warts roommates, and sharing personal items with other persons to be risk factors for warts. Importantly, physical fitness played a protective role against warts. Two hundred and twenty-seven patients in 244 (93.03%) were successfully treated with 5-FU. Multivariate analysis indicated that smoking, alcohol intake, severe psychological stress, more than six months’ duration of cutaneous warts, lesions on foot and warts diameter ≥5 mm adversely affected the effectiveness of 5-FU. Conclusions The newly identified risk factors for cutaneous warts and influence factors for efficacy of 5-FU provided clues for warts prevention and treatment of Chinese Han population. |
| first_indexed | 2024-03-12T00:18:10Z |
| format | Article |
| id | doaj.art-750e6cfc0f1d40df8a0e3c2d9d51e513 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:18:10Z |
| publishDate | 2021-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-750e6cfc0f1d40df8a0e3c2d9d51e5132023-09-15T14:23:03ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532021-04-0132335035410.1080/09546634.2019.16540731654073Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern ChinaZhi P. Xiao0Que P. Liu1Hong F. Xie2Ji Li3Ming L. Chen4Dan Jian5Department of Dermatology, Xiang-Ya Hospital, Central South UniversityDepartment of Dermatology, Xiang-Ya Hospital, Central South UniversityDepartment of Dermatology, Xiang-Ya Hospital, Central South UniversityDepartment of Dermatology, Xiang-Ya Hospital, Central South UniversityDepartment of Dermatology, Xiang-Ya Hospital, Central South UniversityDepartment of Dermatology, Xiang-Ya Hospital, Central South UniversityBackground To systematically explore the risk factors of cutaneous warts and influence factor for the effectiveness of 5-fluorouracil (5-FU). Methods This is a case-control study of 408 cutaneous warts patients and 408 controls of Chinese Han population in southern China. In addition, 244 patients who presented with an initial episode of warts without treatment were treated with intralesional 5-FU. The influence factors of 5-FU therapeutic effects were analyzed. Results After adjustment, we found age (≤14 years old), lower education attainment, alcohol intake, smoking, less daily sleeping hours, severe psychological stress, hyperhidrosis, living in house or apartment, having cutaneous warts roommates, and sharing personal items with other persons to be risk factors for warts. Importantly, physical fitness played a protective role against warts. Two hundred and twenty-seven patients in 244 (93.03%) were successfully treated with 5-FU. Multivariate analysis indicated that smoking, alcohol intake, severe psychological stress, more than six months’ duration of cutaneous warts, lesions on foot and warts diameter ≥5 mm adversely affected the effectiveness of 5-FU. Conclusions The newly identified risk factors for cutaneous warts and influence factors for efficacy of 5-FU provided clues for warts prevention and treatment of Chinese Han population.http://dx.doi.org/10.1080/09546634.2019.1654073wartsrisk factors5-flurouracileffectiveness |
| spellingShingle | Zhi P. Xiao Que P. Liu Hong F. Xie Ji Li Ming L. Chen Dan Jian Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China Journal of Dermatological Treatment warts risk factors 5-flurouracil effectiveness |
| title | Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China |
| title_full | Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China |
| title_fullStr | Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China |
| title_full_unstemmed | Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China |
| title_short | Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China |
| title_sort | risk factors for cutaneous warts and the influence factors of curative effect of 5 flurouracil therapy in southern china |
| topic | warts risk factors 5-flurouracil effectiveness |
| url | http://dx.doi.org/10.1080/09546634.2019.1654073 |
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