Therapeutic options for premature ovarian insufficiency: an updated review
Abstract Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes menstrual disturbances, infertility, and various health problems. Historically, hormone replacement therapy is the first-line treatment for this disorder. Women diagnosed with POI are left with limite...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12958-022-00892-8 |
| _version_ | 1797689046184493056 |
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| author | Qiao-yi Huang Shao-rong Chen Jia-ming Chen Qi-yang Shi Shu Lin |
| author_facet | Qiao-yi Huang Shao-rong Chen Jia-ming Chen Qi-yang Shi Shu Lin |
| author_sort | Qiao-yi Huang |
| collection | DOAJ |
| description | Abstract Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes menstrual disturbances, infertility, and various health problems. Historically, hormone replacement therapy is the first-line treatment for this disorder. Women diagnosed with POI are left with limited therapeutic options. In order to remedy this situation, a new generation of therapeutic approaches, such as in vitro activation, mitochondrial activation technique, stem cell and exosomes therapy, biomaterials strategies, and platelet-rich plasma intra-ovarian infusion, is being developed. However, these emerging therapies are yet in the experimental stage and require precise design components to accelerate their conversion into clinical treatments. Thus, each medical practitioner bears responsibility for selecting suitable therapies for individual patients. In this article, we provide a timely analysis of the therapeutic strategies that are available for POI patients and discuss the prospects of POI therapy. |
| first_indexed | 2024-03-12T01:40:18Z |
| format | Article |
| id | doaj.art-750f3c2c9eba4243b320f86916dafa64 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-03-12T01:40:18Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-750f3c2c9eba4243b320f86916dafa642023-09-10T11:30:15ZengBMCReproductive Biology and Endocrinology1477-78272022-02-0120111610.1186/s12958-022-00892-8Therapeutic options for premature ovarian insufficiency: an updated reviewQiao-yi Huang0Shao-rong Chen1Jia-ming Chen2Qi-yang Shi3Shu Lin4Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical UniversityCentre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical UniversityAbstract Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes menstrual disturbances, infertility, and various health problems. Historically, hormone replacement therapy is the first-line treatment for this disorder. Women diagnosed with POI are left with limited therapeutic options. In order to remedy this situation, a new generation of therapeutic approaches, such as in vitro activation, mitochondrial activation technique, stem cell and exosomes therapy, biomaterials strategies, and platelet-rich plasma intra-ovarian infusion, is being developed. However, these emerging therapies are yet in the experimental stage and require precise design components to accelerate their conversion into clinical treatments. Thus, each medical practitioner bears responsibility for selecting suitable therapies for individual patients. In this article, we provide a timely analysis of the therapeutic strategies that are available for POI patients and discuss the prospects of POI therapy.https://doi.org/10.1186/s12958-022-00892-8Premature ovarian insufficiencyTherapeutic optionsStem cell therapyIn vitro activationMitochondrial activation techniquePlatelet rich plasma |
| spellingShingle | Qiao-yi Huang Shao-rong Chen Jia-ming Chen Qi-yang Shi Shu Lin Therapeutic options for premature ovarian insufficiency: an updated review Reproductive Biology and Endocrinology Premature ovarian insufficiency Therapeutic options Stem cell therapy In vitro activation Mitochondrial activation technique Platelet rich plasma |
| title | Therapeutic options for premature ovarian insufficiency: an updated review |
| title_full | Therapeutic options for premature ovarian insufficiency: an updated review |
| title_fullStr | Therapeutic options for premature ovarian insufficiency: an updated review |
| title_full_unstemmed | Therapeutic options for premature ovarian insufficiency: an updated review |
| title_short | Therapeutic options for premature ovarian insufficiency: an updated review |
| title_sort | therapeutic options for premature ovarian insufficiency an updated review |
| topic | Premature ovarian insufficiency Therapeutic options Stem cell therapy In vitro activation Mitochondrial activation technique Platelet rich plasma |
| url | https://doi.org/10.1186/s12958-022-00892-8 |
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