EFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATION
Objectives: The aim of this study was to evaluate effect of local rifamycin application on BMP-2 expression and bone healing.Materials and Methods: A standardized 5.0-mm- diameter critical size bone defect was created mandible angulus region. In the control group (8 rats) defects were left empty. In...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cumhuriyet University
2017-08-01
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| Series: | Cumhuriyet Dental Journal |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/353570 |
| _version_ | 1827832338507104256 |
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| author | Emin Ün İlker Özeç Ufuk Taşdemir Mustafa Kırtay Hacı Hasan Esen Mustafa Cihat Avunduk |
| author_facet | Emin Ün İlker Özeç Ufuk Taşdemir Mustafa Kırtay Hacı Hasan Esen Mustafa Cihat Avunduk |
| author_sort | Emin Ün |
| collection | DOAJ |
| description | Objectives:
The aim of this study was to evaluate effect of local rifamycin application on
BMP-2 expression and bone healing.Materials and Methods:
A standardized 5.0-mm- diameter critical size bone defect was created mandible
angulus region. In the control group (8 rats) defects were left empty. In the
Group 1 (n=8 rats) defect was irrigated with rifamycin solution and 25 mg
rifamycin solution injected defect area at 1, 3, 7 days after surgery. In the
group 2 (n=8 rats) defects were grafted with a gelatin sponge mixed 25 mg
rifamycin solution. Rats were sacrificed at 21 days after surgery. Histological
slides were prepared from defect site for both immunohistochemical analysis
(bone morphogenetic protein-2 (BMP-2) antibody) and histomorphometric analysis.
Data were analyzed using Mann Whitney U and Kruskall Wallis test.Results:
The average new bone formation, number of osteoblast and new vessel formation
count were increased more in both of experimental groups in comparison with
control group. Anti-BMP-2 labelling (Cell count) was increased more in both of
experimental groups in comparison with control group.
Conclusion:
Local rifamycin application has positive effects on BMP-2 expression and bone regeneration
at critical sized bone defects. |
| first_indexed | 2024-03-12T05:10:43Z |
| format | Article |
| id | doaj.art-750fcb4569464d35b1f1531a1e6197cf |
| institution | Directory Open Access Journal |
| issn | 1302-5805 2146-2852 |
| language | English |
| last_indexed | 2024-03-12T05:10:43Z |
| publishDate | 2017-08-01 |
| publisher | Cumhuriyet University |
| record_format | Article |
| series | Cumhuriyet Dental Journal |
| spelling | doaj.art-750fcb4569464d35b1f1531a1e6197cf2023-09-03T08:41:29ZengCumhuriyet UniversityCumhuriyet Dental Journal1302-58052146-28522017-08-01202808710.7126/cumudj.3459342057EFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATIONEmin Ünİlker ÖzeçUfuk TaşdemirMustafa KırtayHacı Hasan EsenMustafa Cihat AvundukObjectives: The aim of this study was to evaluate effect of local rifamycin application on BMP-2 expression and bone healing.Materials and Methods: A standardized 5.0-mm- diameter critical size bone defect was created mandible angulus region. In the control group (8 rats) defects were left empty. In the Group 1 (n=8 rats) defect was irrigated with rifamycin solution and 25 mg rifamycin solution injected defect area at 1, 3, 7 days after surgery. In the group 2 (n=8 rats) defects were grafted with a gelatin sponge mixed 25 mg rifamycin solution. Rats were sacrificed at 21 days after surgery. Histological slides were prepared from defect site for both immunohistochemical analysis (bone morphogenetic protein-2 (BMP-2) antibody) and histomorphometric analysis. Data were analyzed using Mann Whitney U and Kruskall Wallis test.Results: The average new bone formation, number of osteoblast and new vessel formation count were increased more in both of experimental groups in comparison with control group. Anti-BMP-2 labelling (Cell count) was increased more in both of experimental groups in comparison with control group. Conclusion: Local rifamycin application has positive effects on BMP-2 expression and bone regeneration at critical sized bone defects.https://dergipark.org.tr/tr/download/article-file/353570rifamisinkritik boyutta kemik defektikemik rejenerasyonukemik morfogenetik protein – 2rifamycincritical sized bone defectbone regenerationbone morphogenetic protein – 2 |
| spellingShingle | Emin Ün İlker Özeç Ufuk Taşdemir Mustafa Kırtay Hacı Hasan Esen Mustafa Cihat Avunduk EFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATION Cumhuriyet Dental Journal rifamisin kritik boyutta kemik defekti kemik rejenerasyonu kemik morfogenetik protein – 2 rifamycin critical sized bone defect bone regeneration bone morphogenetic protein – 2 |
| title | EFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATION |
| title_full | EFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATION |
| title_fullStr | EFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATION |
| title_full_unstemmed | EFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATION |
| title_short | EFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATION |
| title_sort | effect of local rifamycin application on expression of bmp 2 and bone regeneration |
| topic | rifamisin kritik boyutta kemik defekti kemik rejenerasyonu kemik morfogenetik protein – 2 rifamycin critical sized bone defect bone regeneration bone morphogenetic protein – 2 |
| url | https://dergipark.org.tr/tr/download/article-file/353570 |
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