Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons

Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons

Tau phosphorylated at the PHF-1 epitope (S396/S404) is likely involved in the pathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms by which tau phosphorylated at these sites negatively impacts neuronal functions are still under scrutiny. Previously, we showed that express...

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Bibliographic Details
Main Authors: Rodrigo A. Quintanilla, Rommy von Bernhardi, Juan A. Godoy, Nibaldo C. Inestrosa, Gail V.W. Johnson
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Neurobiology of Disease
Subjects:
Tau
PHF-1
Mitochondria
Neuronal dysfunction
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002472

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