Immune Response to Vaccination against COVID-19 in Breastfeeding Health Workers
Background: Initially, there were no data on the safety of COVID-19 vaccines in lactating women. The aim of our study was to evaluate the immune response to COVID-19 vaccinations in breastfeeding women. Methods: The study included 32 breastfeeding women who, regardless of the study, had decided to b...
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MDPI AG
2021-06-01
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Series: | Vaccines |
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Online Access: | https://www.mdpi.com/2076-393X/9/6/663 |
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author | Katarzyna Jakuszko Katarzyna Kościelska-Kasprzak Marcelina Żabińska Dorota Bartoszek Paweł Poznański Dagna Rukasz Renata Kłak Barbara Królak-Olejnik Magdalena Krajewska |
author_facet | Katarzyna Jakuszko Katarzyna Kościelska-Kasprzak Marcelina Żabińska Dorota Bartoszek Paweł Poznański Dagna Rukasz Renata Kłak Barbara Królak-Olejnik Magdalena Krajewska |
author_sort | Katarzyna Jakuszko |
collection | DOAJ |
description | Background: Initially, there were no data on the safety of COVID-19 vaccines in lactating women. The aim of our study was to evaluate the immune response to COVID-19 vaccinations in breastfeeding women. Methods: The study included 32 breastfeeding women who, regardless of the study, had decided to be vaccinated. Maternal serum and breast milk samples were simultaneously collected on days 8 ± 1, 22 ± 2, 29 ± 3, and 43 ± 4 after the first dose of the vaccine. The immune response was assessed by determining the presence of anti-SARS-CoV-2 IgG and IgA. Results: The breast milk IgG level was detectable (6.50 ± 6.74, median 4.7, and maximum 34.2 BAU/mL) and highly correlated to serum IgG level (r<sub>S</sub> 0.89; <i>p</i> < 0.001). The breast milk ratio of IgA to the cut-off value was higher in serum IgA-positive (4.18 ± 3.26, median 2.8, and maximum >10) than in serum IgA-negative women (0.56 ± 0.37, median 0.5, and maximum 1.6; <i>p</i> < 0.001). The highest concentrations of serum and breast milk antibodies were observed on day 29 ± 3 with a decrease on day 43 ± 4. Conclusion: The immune response to the vaccination against SARS-CoV-2 is strongest 7 ± 3 days after the second dose of the vaccine. Lactating mothers breastfeeding their children after vaccination against SARS-CoV-2 may transfer antibodies to their infant. |
first_indexed | 2024-03-10T10:19:35Z |
format | Article |
id | doaj.art-75145a7b5d9443f591933fdefee8e767 |
institution | Directory Open Access Journal |
issn | 2076-393X |
language | English |
last_indexed | 2024-03-10T10:19:35Z |
publishDate | 2021-06-01 |
publisher | MDPI AG |
record_format | Article |
series | Vaccines |
spelling | doaj.art-75145a7b5d9443f591933fdefee8e7672023-11-22T00:34:17ZengMDPI AGVaccines2076-393X2021-06-019666310.3390/vaccines9060663Immune Response to Vaccination against COVID-19 in Breastfeeding Health WorkersKatarzyna Jakuszko0Katarzyna Kościelska-Kasprzak1Marcelina Żabińska2Dorota Bartoszek3Paweł Poznański4Dagna Rukasz5Renata Kłak6Barbara Królak-Olejnik7Magdalena Krajewska8Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Neonatology, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-367 Wroclaw, PolandBackground: Initially, there were no data on the safety of COVID-19 vaccines in lactating women. The aim of our study was to evaluate the immune response to COVID-19 vaccinations in breastfeeding women. Methods: The study included 32 breastfeeding women who, regardless of the study, had decided to be vaccinated. Maternal serum and breast milk samples were simultaneously collected on days 8 ± 1, 22 ± 2, 29 ± 3, and 43 ± 4 after the first dose of the vaccine. The immune response was assessed by determining the presence of anti-SARS-CoV-2 IgG and IgA. Results: The breast milk IgG level was detectable (6.50 ± 6.74, median 4.7, and maximum 34.2 BAU/mL) and highly correlated to serum IgG level (r<sub>S</sub> 0.89; <i>p</i> < 0.001). The breast milk ratio of IgA to the cut-off value was higher in serum IgA-positive (4.18 ± 3.26, median 2.8, and maximum >10) than in serum IgA-negative women (0.56 ± 0.37, median 0.5, and maximum 1.6; <i>p</i> < 0.001). The highest concentrations of serum and breast milk antibodies were observed on day 29 ± 3 with a decrease on day 43 ± 4. Conclusion: The immune response to the vaccination against SARS-CoV-2 is strongest 7 ± 3 days after the second dose of the vaccine. Lactating mothers breastfeeding their children after vaccination against SARS-CoV-2 may transfer antibodies to their infant.https://www.mdpi.com/2076-393X/9/6/663breast milkbreastfeedinganti-SARS-CoV-2 antibodieslactationCOVID-19vaccination |
spellingShingle | Katarzyna Jakuszko Katarzyna Kościelska-Kasprzak Marcelina Żabińska Dorota Bartoszek Paweł Poznański Dagna Rukasz Renata Kłak Barbara Królak-Olejnik Magdalena Krajewska Immune Response to Vaccination against COVID-19 in Breastfeeding Health Workers Vaccines breast milk breastfeeding anti-SARS-CoV-2 antibodies lactation COVID-19 vaccination |
title | Immune Response to Vaccination against COVID-19 in Breastfeeding Health Workers |
title_full | Immune Response to Vaccination against COVID-19 in Breastfeeding Health Workers |
title_fullStr | Immune Response to Vaccination against COVID-19 in Breastfeeding Health Workers |
title_full_unstemmed | Immune Response to Vaccination against COVID-19 in Breastfeeding Health Workers |
title_short | Immune Response to Vaccination against COVID-19 in Breastfeeding Health Workers |
title_sort | immune response to vaccination against covid 19 in breastfeeding health workers |
topic | breast milk breastfeeding anti-SARS-CoV-2 antibodies lactation COVID-19 vaccination |
url | https://www.mdpi.com/2076-393X/9/6/663 |
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