Catalytic green synthesis of Tin(IV) oxide nanoparticles for phenolic compounds removal and molecular docking with EGFR tyrosine kinase
Abstract In this study, tin dioxide nanoparticles (SnO2 NPs) were successfully synthesized through an eco-friendly method using basil leaves extract. The fabricated SnO2 NPs demonstrated significant adsorption capabilities for phenol (PHE), p-nitrophenol (P-NP), and p-methoxyphenol (P-MP) from water...
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-55460-4 |
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| author | S. F. Alshahateet R. M. Altarawneh W. M. Al-Tawarh S. A. Al-Trawneh S. Al-Taweel K. Azzaoui M. Merzouki R. Sabbahi B. Hammouti G. Hanbali S. Jodeh |
| author_facet | S. F. Alshahateet R. M. Altarawneh W. M. Al-Tawarh S. A. Al-Trawneh S. Al-Taweel K. Azzaoui M. Merzouki R. Sabbahi B. Hammouti G. Hanbali S. Jodeh |
| author_sort | S. F. Alshahateet |
| collection | DOAJ |
| description | Abstract In this study, tin dioxide nanoparticles (SnO2 NPs) were successfully synthesized through an eco-friendly method using basil leaves extract. The fabricated SnO2 NPs demonstrated significant adsorption capabilities for phenol (PHE), p-nitrophenol (P-NP), and p-methoxyphenol (P-MP) from water matrices. Optimal conditions for maximum removal efficiency was determined for each phenolic compound, with PHE showing a remarkable 95% removal at a 3 ppm, 0.20 g of SnO2 NPs, pH 8, and 30 min of agitation at 35 °C. Molecular docking studies unveiled a potential anticancer mechanism, indicating the ability of SnO2 NPs to interact with the epidermal growth factor receptor tyrosine kinase domain and inhibit its activity. The adsorption processes followed pseudo-second order kinetics and Temkin isotherm model, revealing spontaneous, exothermic, and chemisorption-controlled mechanisms. This eco-friendly approach utilizing plant extracts was considered as a valuable tool for nano-sorbent production. The SnO2 NPs not only exhibit promise in water treatment and also demonstrate potential applications in cancer therapy. Characterization techniques including scanning electron microscopy, UV–visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction spectroscopy (XRD), and energy-dispersive X-ray spectroscopy (EDAX) provided comprehensive insights into the results. |
| first_indexed | 2024-04-24T12:39:26Z |
| format | Article |
| id | doaj.art-751524739aa547a795511a82df26b0e5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T12:39:26Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-751524739aa547a795511a82df26b0e52024-04-07T11:18:52ZengNature PortfolioScientific Reports2045-23222024-03-0114111710.1038/s41598-024-55460-4Catalytic green synthesis of Tin(IV) oxide nanoparticles for phenolic compounds removal and molecular docking with EGFR tyrosine kinaseS. F. Alshahateet0R. M. Altarawneh1W. M. Al-Tawarh2S. A. Al-Trawneh3S. Al-Taweel4K. Azzaoui5M. Merzouki6R. Sabbahi7B. Hammouti8G. Hanbali9S. Jodeh10Department of Chemistry, Faculty of Science, Mutah UniversityDepartment of Chemistry, Faculty of Science, Mutah UniversityDepartment of Chemistry, Faculty of Science, Mutah UniversityDepartment of Chemistry, Faculty of Science, Mutah UniversityDepartment of Chemistry, Faculty of Science, Mutah UniversityEngineering Laboratory of Organometallic, Molecular Materials and Environment, Faculty of Sciences, Sidi Mohamed Ben Abdellah UniversityMorocco Laboratory of Applied Chemistry and Environment (LCAE) Team (ECOMP), Mohamed 1er UniversityEuro-Mediterranean University of FesEuro-Mediterranean University of FesDepartment of Chemistry, An-Najah National UniversityDepartment of Chemistry, An-Najah National UniversityAbstract In this study, tin dioxide nanoparticles (SnO2 NPs) were successfully synthesized through an eco-friendly method using basil leaves extract. The fabricated SnO2 NPs demonstrated significant adsorption capabilities for phenol (PHE), p-nitrophenol (P-NP), and p-methoxyphenol (P-MP) from water matrices. Optimal conditions for maximum removal efficiency was determined for each phenolic compound, with PHE showing a remarkable 95% removal at a 3 ppm, 0.20 g of SnO2 NPs, pH 8, and 30 min of agitation at 35 °C. Molecular docking studies unveiled a potential anticancer mechanism, indicating the ability of SnO2 NPs to interact with the epidermal growth factor receptor tyrosine kinase domain and inhibit its activity. The adsorption processes followed pseudo-second order kinetics and Temkin isotherm model, revealing spontaneous, exothermic, and chemisorption-controlled mechanisms. This eco-friendly approach utilizing plant extracts was considered as a valuable tool for nano-sorbent production. The SnO2 NPs not only exhibit promise in water treatment and also demonstrate potential applications in cancer therapy. Characterization techniques including scanning electron microscopy, UV–visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction spectroscopy (XRD), and energy-dispersive X-ray spectroscopy (EDAX) provided comprehensive insights into the results.https://doi.org/10.1038/s41598-024-55460-4Green synthesisSnO2 NPsOcimum basilicumAdsorptionPhenolp-Nitrophenol |
| spellingShingle | S. F. Alshahateet R. M. Altarawneh W. M. Al-Tawarh S. A. Al-Trawneh S. Al-Taweel K. Azzaoui M. Merzouki R. Sabbahi B. Hammouti G. Hanbali S. Jodeh Catalytic green synthesis of Tin(IV) oxide nanoparticles for phenolic compounds removal and molecular docking with EGFR tyrosine kinase Scientific Reports Green synthesis SnO2 NPs Ocimum basilicum Adsorption Phenol p-Nitrophenol |
| title | Catalytic green synthesis of Tin(IV) oxide nanoparticles for phenolic compounds removal and molecular docking with EGFR tyrosine kinase |
| title_full | Catalytic green synthesis of Tin(IV) oxide nanoparticles for phenolic compounds removal and molecular docking with EGFR tyrosine kinase |
| title_fullStr | Catalytic green synthesis of Tin(IV) oxide nanoparticles for phenolic compounds removal and molecular docking with EGFR tyrosine kinase |
| title_full_unstemmed | Catalytic green synthesis of Tin(IV) oxide nanoparticles for phenolic compounds removal and molecular docking with EGFR tyrosine kinase |
| title_short | Catalytic green synthesis of Tin(IV) oxide nanoparticles for phenolic compounds removal and molecular docking with EGFR tyrosine kinase |
| title_sort | catalytic green synthesis of tin iv oxide nanoparticles for phenolic compounds removal and molecular docking with egfr tyrosine kinase |
| topic | Green synthesis SnO2 NPs Ocimum basilicum Adsorption Phenol p-Nitrophenol |
| url | https://doi.org/10.1038/s41598-024-55460-4 |
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