Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus
Trichodermanins C–E (1–3), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus Trichoderma harzianum OUPS-111D-4 separated from a piece of a marine sponge Halichondria okadai, and these chemical structures have been established by spectroscopic analyses using IR, M...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-06-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/15/6/169 |
| _version_ | 1818015441481629696 |
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| author | Takeshi Yamada Mayo Suzue Takanobu Arai Takashi Kikuchi Reiko Tanaka |
| author_facet | Takeshi Yamada Mayo Suzue Takanobu Arai Takashi Kikuchi Reiko Tanaka |
| author_sort | Takeshi Yamada |
| collection | DOAJ |
| description | Trichodermanins C–E (1–3), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus Trichoderma harzianum OUPS-111D-4 separated from a piece of a marine sponge Halichondria okadai, and these chemical structures have been established by spectroscopic analyses using IR, MASS, HRFABMS, and NMR spectra. We established their absolute stereostructures by application of the modified Mosher’s method. In addition, 1 inhibited the growth of cancer cell lines potently. |
| first_indexed | 2024-04-14T06:58:04Z |
| format | Article |
| id | doaj.art-751587abebca4c81a4ecb12ec8f7f95a |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T06:58:04Z |
| publishDate | 2017-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-751587abebca4c81a4ecb12ec8f7f95a2022-12-22T02:06:50ZengMDPI AGMarine Drugs1660-33972017-06-0115616910.3390/md15060169md15060169Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived FungusTakeshi Yamada0Mayo Suzue1Takanobu Arai2Takashi Kikuchi3Reiko Tanaka4Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1142, JapanFaculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1142, JapanFaculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1142, JapanFaculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1142, JapanFaculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1142, JapanTrichodermanins C–E (1–3), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus Trichoderma harzianum OUPS-111D-4 separated from a piece of a marine sponge Halichondria okadai, and these chemical structures have been established by spectroscopic analyses using IR, MASS, HRFABMS, and NMR spectra. We established their absolute stereostructures by application of the modified Mosher’s method. In addition, 1 inhibited the growth of cancer cell lines potently.http://www.mdpi.com/1660-3397/15/6/169trichodermaninsTrichoderma harzianummarine microorganismHalichondria okadaiditerpenes6-5-6-6 ring systemcytotoxicity |
| spellingShingle | Takeshi Yamada Mayo Suzue Takanobu Arai Takashi Kikuchi Reiko Tanaka Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus Marine Drugs trichodermanins Trichoderma harzianum marine microorganism Halichondria okadai diterpenes 6-5-6-6 ring system cytotoxicity |
| title | Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus |
| title_full | Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus |
| title_fullStr | Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus |
| title_full_unstemmed | Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus |
| title_short | Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus |
| title_sort | trichodermanins c e new diterpenes with a fused 6 5 6 6 ring system produced by a marine sponge derived fungus |
| topic | trichodermanins Trichoderma harzianum marine microorganism Halichondria okadai diterpenes 6-5-6-6 ring system cytotoxicity |
| url | http://www.mdpi.com/1660-3397/15/6/169 |
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