Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury
Ischemia-reperfusion injury (IRI) is a severe condition for most organs, which could occur in various tissues including brain, heart, liver, and kidney, etc. As one of the major hazards, reactive oxygen species (ROS) is excessively generated after IRI, which causes severe damage inside tissues and f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2020.00732/full |
| _version_ | 1818322965515730944 |
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| author | Weiyu Chen Weiyu Chen Deling Li |
| author_facet | Weiyu Chen Weiyu Chen Deling Li |
| author_sort | Weiyu Chen |
| collection | DOAJ |
| description | Ischemia-reperfusion injury (IRI) is a severe condition for most organs, which could occur in various tissues including brain, heart, liver, and kidney, etc. As one of the major hazards, reactive oxygen species (ROS) is excessively generated after IRI, which causes severe damage inside tissues and further induces the following injury via inflammatory response. However, current medical strategies could not thoroughly diagnose and prevent this disease, eventually leading to severe sequelae by missing the best time point for therapy. In the past decade, various nanoparticles that could selectively respond to ROS have been developed and applied in IRI. These advanced nanomedicines have shown efficient performance in detecting and treating a series of IRI (e.g., acute kidney injury, acute liver injury, and ischemic stroke, etc.), which are well-summarized in the current review. In addition, the nano-platforms (e.g., anti-IL-6 antibody, rapamycin, and hydrogen sulfide delivering nanoparticles, etc.) for preventing IRI during organ transplantation have also been included. Moreover, the development and challenges of ROS-responsive nanomedicine are systematically discussed for guiding the future direction. |
| first_indexed | 2024-12-13T11:05:11Z |
| format | Article |
| id | doaj.art-7518045663f0499e8c35dd7c1a6fe59b |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-13T11:05:11Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-7518045663f0499e8c35dd7c1a6fe59b2022-12-21T23:49:02ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462020-08-01810.3389/fchem.2020.00732576088Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion InjuryWeiyu Chen0Weiyu Chen1Deling Li2The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, ChinaMolecular Imaging Program at Stanford, Department of Radiology, Stanford University, Stanford, CA, United StatesDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaIschemia-reperfusion injury (IRI) is a severe condition for most organs, which could occur in various tissues including brain, heart, liver, and kidney, etc. As one of the major hazards, reactive oxygen species (ROS) is excessively generated after IRI, which causes severe damage inside tissues and further induces the following injury via inflammatory response. However, current medical strategies could not thoroughly diagnose and prevent this disease, eventually leading to severe sequelae by missing the best time point for therapy. In the past decade, various nanoparticles that could selectively respond to ROS have been developed and applied in IRI. These advanced nanomedicines have shown efficient performance in detecting and treating a series of IRI (e.g., acute kidney injury, acute liver injury, and ischemic stroke, etc.), which are well-summarized in the current review. In addition, the nano-platforms (e.g., anti-IL-6 antibody, rapamycin, and hydrogen sulfide delivering nanoparticles, etc.) for preventing IRI during organ transplantation have also been included. Moreover, the development and challenges of ROS-responsive nanomedicine are systematically discussed for guiding the future direction.https://www.frontiersin.org/article/10.3389/fchem.2020.00732/fullbioresponsive nanomedicineischemia-reperfusion injuryreactive oxygen speciesorgan transplantationnanoparticles |
| spellingShingle | Weiyu Chen Weiyu Chen Deling Li Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury Frontiers in Chemistry bioresponsive nanomedicine ischemia-reperfusion injury reactive oxygen species organ transplantation nanoparticles |
| title | Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury |
| title_full | Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury |
| title_fullStr | Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury |
| title_full_unstemmed | Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury |
| title_short | Reactive Oxygen Species (ROS)-Responsive Nanomedicine for Solving Ischemia-Reperfusion Injury |
| title_sort | reactive oxygen species ros responsive nanomedicine for solving ischemia reperfusion injury |
| topic | bioresponsive nanomedicine ischemia-reperfusion injury reactive oxygen species organ transplantation nanoparticles |
| url | https://www.frontiersin.org/article/10.3389/fchem.2020.00732/full |
| work_keys_str_mv | AT weiyuchen reactiveoxygenspeciesrosresponsivenanomedicineforsolvingischemiareperfusioninjury AT weiyuchen reactiveoxygenspeciesrosresponsivenanomedicineforsolvingischemiareperfusioninjury AT delingli reactiveoxygenspeciesrosresponsivenanomedicineforsolvingischemiareperfusioninjury |