Susceptibility to Teicoplanin and Daptomycin among Coagulase-Negative Staphylococci Isolated from Bloodstream Infections in Patients with Hematological Malignancies
Introduction: Recently, a decreased susceptibility to teicoplanin has been observed among coagulase-negative staphylococci (CNS) isolated from bloodstream infections in patients with hematological malignancies. In this study, we aimed to determine the minimum inhibitory concentrations (MIC) of teico...
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| Format: | Article |
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Bilimsel Tip Yayinevi
2011-06-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
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| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2011-16-2-067-070.pdf |
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| author | Özlem GÜZEL TUNÇCAN Derya TOZLU KETEN Murat DİZBAY Esin ŞENOL |
| author_facet | Özlem GÜZEL TUNÇCAN Derya TOZLU KETEN Murat DİZBAY Esin ŞENOL |
| author_sort | Özlem GÜZEL TUNÇCAN |
| collection | DOAJ |
| description | Introduction: Recently, a decreased susceptibility to teicoplanin has been observed among coagulase-negative staphylococci (CNS) isolated from bloodstream infections in patients with hematological malignancies. In this study, we aimed to determine the minimum inhibitory concentrations (MIC) of teicoplanin, which is frequently used in the empirical treatment, and of a new agent, daptomycin, against CNS isolated from bloodstream infections. Materials and Methods: The study was performed on CNS strains isolated from bloodstream infections of patients with hematological malignancies during the period 2009-2011. Susceptibility to oxacillin was tested by disk diffusion method. Daptomycin and teicoplanin MIC were determined using the E-test method. Results: A total of 179 CNS strains causing bloodstream infections were studied. Among them, S. epidermidis (36.3%) and S. haemolyticus (35.2%) were the most frequent CNS species. The oxacillin resistance rate was found statistically higher among S. haemolyticus (61%) strains than among S. epidermidis (32%) (p= 0.001). Although teicoplanin and daptomycin resistance was not detected among the CNS isolates, two (1.1%) of the isolates demonstrated intermediate susceptibility to teicoplanin. Conclusions: S. haemolyticus and S. epidermidis were the major causes of bloodstream infections in patients with hematological malignancies. Oxacillin resistance was more frequent among S. haemolyticus isolates. Teicoplanin resistance was not detected among the CNS isolates. However, because two of the isolates demonstrated decreased susceptibility to teicoplanin, resistance rates to teicoplanin should be closely monitored. Daptomycin was found to be effective against both oxacillin-resistant and teicoplanin-intermediate CNS isolates. |
| first_indexed | 2024-04-10T12:18:55Z |
| format | Article |
| id | doaj.art-751c44f9ee374d63a5f26927fea89391 |
| institution | Directory Open Access Journal |
| issn | 1300-932X 1300-932X |
| language | English |
| last_indexed | 2024-04-10T12:18:55Z |
| publishDate | 2011-06-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-751c44f9ee374d63a5f26927fea893912023-02-15T16:15:33ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X1300-932X2011-06-011626770Susceptibility to Teicoplanin and Daptomycin among Coagulase-Negative Staphylococci Isolated from Bloodstream Infections in Patients with Hematological MalignanciesÖzlem GÜZEL TUNÇCAN0Derya TOZLU KETEN1Murat DİZBAY2Esin ŞENOL3Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Gazi, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Gazi, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Gazi, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Gazi, Ankara, TurkeyIntroduction: Recently, a decreased susceptibility to teicoplanin has been observed among coagulase-negative staphylococci (CNS) isolated from bloodstream infections in patients with hematological malignancies. In this study, we aimed to determine the minimum inhibitory concentrations (MIC) of teicoplanin, which is frequently used in the empirical treatment, and of a new agent, daptomycin, against CNS isolated from bloodstream infections. Materials and Methods: The study was performed on CNS strains isolated from bloodstream infections of patients with hematological malignancies during the period 2009-2011. Susceptibility to oxacillin was tested by disk diffusion method. Daptomycin and teicoplanin MIC were determined using the E-test method. Results: A total of 179 CNS strains causing bloodstream infections were studied. Among them, S. epidermidis (36.3%) and S. haemolyticus (35.2%) were the most frequent CNS species. The oxacillin resistance rate was found statistically higher among S. haemolyticus (61%) strains than among S. epidermidis (32%) (p= 0.001). Although teicoplanin and daptomycin resistance was not detected among the CNS isolates, two (1.1%) of the isolates demonstrated intermediate susceptibility to teicoplanin. Conclusions: S. haemolyticus and S. epidermidis were the major causes of bloodstream infections in patients with hematological malignancies. Oxacillin resistance was more frequent among S. haemolyticus isolates. Teicoplanin resistance was not detected among the CNS isolates. However, because two of the isolates demonstrated decreased susceptibility to teicoplanin, resistance rates to teicoplanin should be closely monitored. Daptomycin was found to be effective against both oxacillin-resistant and teicoplanin-intermediate CNS isolates.http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2011-16-2-067-070.pdfBloodstream infectionCoagulase-negative staphylococciTeicoplaninDaptomycin |
| spellingShingle | Özlem GÜZEL TUNÇCAN Derya TOZLU KETEN Murat DİZBAY Esin ŞENOL Susceptibility to Teicoplanin and Daptomycin among Coagulase-Negative Staphylococci Isolated from Bloodstream Infections in Patients with Hematological Malignancies Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi Bloodstream infection Coagulase-negative staphylococci Teicoplanin Daptomycin |
| title | Susceptibility to Teicoplanin and Daptomycin among Coagulase-Negative Staphylococci Isolated from Bloodstream Infections in Patients with Hematological Malignancies |
| title_full | Susceptibility to Teicoplanin and Daptomycin among Coagulase-Negative Staphylococci Isolated from Bloodstream Infections in Patients with Hematological Malignancies |
| title_fullStr | Susceptibility to Teicoplanin and Daptomycin among Coagulase-Negative Staphylococci Isolated from Bloodstream Infections in Patients with Hematological Malignancies |
| title_full_unstemmed | Susceptibility to Teicoplanin and Daptomycin among Coagulase-Negative Staphylococci Isolated from Bloodstream Infections in Patients with Hematological Malignancies |
| title_short | Susceptibility to Teicoplanin and Daptomycin among Coagulase-Negative Staphylococci Isolated from Bloodstream Infections in Patients with Hematological Malignancies |
| title_sort | susceptibility to teicoplanin and daptomycin among coagulase negative staphylococci isolated from bloodstream infections in patients with hematological malignancies |
| topic | Bloodstream infection Coagulase-negative staphylococci Teicoplanin Daptomycin |
| url | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2011-16-2-067-070.pdf |
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