Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome.

Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome.

During infection of mammalian hosts, African trypanosomes thwart immunity using antigenic variation of the dense Variant Surface Glycoprotein (VSG) coat, accessing a large repertoire of several thousand genes and pseudogenes, and switching to antigenically distinct copies. The parasite is transferre...

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Bibliographic Details
Main Authors: Monica Chandra, Sara Đaković, Konstantina Foti, Johan P Zeelen, Monique van Straaten, Francisco Aresta-Branco, Eliane Tihon, Nicole Lübbehusen, Thomas Ruppert, Lucy Glover, F Nina Papavasiliou, C Erec Stebbins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0011093

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