Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta Crantz (yuca) in an experimental model of acute inflammation
Introduction: Manihot esculenta Crantz (yucca) leaves have been used around the world and over time in order to decrease the anti-inflammatory response. Objective: To evaluate the anti-inflammatory activity of the ethanolic extract of the Manihot esculenta Crantz leaf in rats. Methods: An experiment...
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| Format: | Article |
| Language: | Spanish |
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Universidad Ricardo Palma
2020-01-01
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| Series: | Revista de la Facultad de Medicina Humana |
| Subjects: | |
| Online Access: | http://revistas.urp.edu.pe/index.php/RFMH/article/view/2552 |
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| author | Nathalie D. Amado-Cornejo Geraldine Atusparia-Flores Maricielo V. Huamán-Cabrera Ángela Méndez-Pajares Etty Prado-Asencios Hilda Jurupe-Chico Vilma Herencia-Reyes |
| author_facet | Nathalie D. Amado-Cornejo Geraldine Atusparia-Flores Maricielo V. Huamán-Cabrera Ángela Méndez-Pajares Etty Prado-Asencios Hilda Jurupe-Chico Vilma Herencia-Reyes |
| author_sort | Nathalie D. Amado-Cornejo |
| collection | DOAJ |
| description | Introduction: Manihot esculenta Crantz (yucca) leaves have been used around the world and over time in order to decrease the anti-inflammatory response. Objective: To evaluate the anti-inflammatory activity of the ethanolic extract of the Manihot esculenta Crantz leaf in rats. Methods: An experimental study was conducted. The study population included 60 albino rats sp. Rattus novergicus, distributed in 4 groups of 15 rats each. A homogeneous solution of ethanolic extract of Manihot esculenta Crantz leaves was used for intraperitoneal administration. Carrageenan was used as an inflammatory inducer that was administered intradermally; for the measurement of plantar edema, the Digital Water Plethysmometer (LE7500) was used. Tween 80 / water solution (1:10) was administered to the negative control group at a dose of 1mL./100g., To the betamethasone positive control group 4mg / Kg and to treatment groups 1 and 2 Manihot esculenta Crantz, 2 mg / kg and 4 mg / kg, respectively. The 1-tail ANOVA test and the Tukey post hoc test were used for comparisons between the groups. Results: In 37.67% of treatment group 2 a reduction in edema was observed 3 hours after administering Manihot esculenta Crantz (p <0.05). In both administration groups of Manihot esculenta Crantz there was a nonsignificant trend to reduce plantar edema with values close to significance. Conclusion: The Manihot esculenta Crantz ethanolic extract at a 4 mg / kg dose probably have anti-inflammatory activity in this animal model of acute inflamation. |
| first_indexed | 2024-12-11T11:55:20Z |
| format | Article |
| id | doaj.art-751e329a6cda4e8f926caa6d5e09fad2 |
| institution | Directory Open Access Journal |
| issn | 1814-5469 2308-0531 |
| language | Spanish |
| last_indexed | 2024-12-11T11:55:20Z |
| publishDate | 2020-01-01 |
| publisher | Universidad Ricardo Palma |
| record_format | Article |
| series | Revista de la Facultad de Medicina Humana |
| spelling | doaj.art-751e329a6cda4e8f926caa6d5e09fad22022-12-22T01:08:13ZspaUniversidad Ricardo PalmaRevista de la Facultad de Medicina Humana1814-54692308-05312020-01-01201949810.25176/RFMH.v20i1.2552Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta Crantz (yuca) in an experimental model of acute inflammationNathalie D. Amado-Cornejo0Geraldine Atusparia-Flores1Maricielo V. Huamán-Cabrera2Ángela Méndez-Pajares3Etty Prado-Asencios4Hilda Jurupe-Chico5Vilma Herencia-Reyes6 https://orcid.org/0000-0002-4899-4636 https://orcid.org/0000-0002-2621-3704 https://orcid.org/0000-0003-1493-7294 https://orcid.org/0000-0003-2628-0242 https://orcid.org/0000-0001-7269-2980 https://orcid.org/0000-0002-0833-7180 https://orcid.org/0000-0002-6086-9264Introduction: Manihot esculenta Crantz (yucca) leaves have been used around the world and over time in order to decrease the anti-inflammatory response. Objective: To evaluate the anti-inflammatory activity of the ethanolic extract of the Manihot esculenta Crantz leaf in rats. Methods: An experimental study was conducted. The study population included 60 albino rats sp. Rattus novergicus, distributed in 4 groups of 15 rats each. A homogeneous solution of ethanolic extract of Manihot esculenta Crantz leaves was used for intraperitoneal administration. Carrageenan was used as an inflammatory inducer that was administered intradermally; for the measurement of plantar edema, the Digital Water Plethysmometer (LE7500) was used. Tween 80 / water solution (1:10) was administered to the negative control group at a dose of 1mL./100g., To the betamethasone positive control group 4mg / Kg and to treatment groups 1 and 2 Manihot esculenta Crantz, 2 mg / kg and 4 mg / kg, respectively. The 1-tail ANOVA test and the Tukey post hoc test were used for comparisons between the groups. Results: In 37.67% of treatment group 2 a reduction in edema was observed 3 hours after administering Manihot esculenta Crantz (p <0.05). In both administration groups of Manihot esculenta Crantz there was a nonsignificant trend to reduce plantar edema with values close to significance. Conclusion: The Manihot esculenta Crantz ethanolic extract at a 4 mg / kg dose probably have anti-inflammatory activity in this animal model of acute inflamation.http://revistas.urp.edu.pe/index.php/RFMH/article/view/2552manihot esculenta crantzinflammationedema |
| spellingShingle | Nathalie D. Amado-Cornejo Geraldine Atusparia-Flores Maricielo V. Huamán-Cabrera Ángela Méndez-Pajares Etty Prado-Asencios Hilda Jurupe-Chico Vilma Herencia-Reyes Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta Crantz (yuca) in an experimental model of acute inflammation Revista de la Facultad de Medicina Humana manihot esculenta crantz inflammation edema |
| title | Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta Crantz (yuca) in an experimental model of acute inflammation |
| title_full | Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta Crantz (yuca) in an experimental model of acute inflammation |
| title_fullStr | Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta Crantz (yuca) in an experimental model of acute inflammation |
| title_full_unstemmed | Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta Crantz (yuca) in an experimental model of acute inflammation |
| title_short | Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta Crantz (yuca) in an experimental model of acute inflammation |
| title_sort | anti inflammatory activity of the ethnolic extract of the leaves of manihot esculenta crantz yuca in an experimental model of acute inflammation |
| topic | manihot esculenta crantz inflammation edema |
| url | http://revistas.urp.edu.pe/index.php/RFMH/article/view/2552 |
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