<i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide

<i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide

<i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide was prepared by a reaction between tryptamine and flurbiprofen, applying <i>N</i>,<i>N’</i>-Dicyclohexylcarbodiimide, as a coupling agent. The obtained new amide has...

Full description

Bibliographic Details
Main Authors:	Stanimir Manolov, Iliyan Ivanov, Dimitar Bojilov
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	Molbank
Subjects:	amide flurbiprofen SARS-CoV-2 tryptamine
Online Access:	https://www.mdpi.com/1422-8599/2021/1/M1177

Description
Summary:	<i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide was prepared by a reaction between tryptamine and flurbiprofen, applying <i>N</i>,<i>N’</i>-Dicyclohexylcarbodiimide, as a coupling agent. The obtained new amide has a fragment similar to <i>Brequinar</i>, a compound used in SARS-CoV-2 treatment trials. The newly synthesized compound was fully analyzed and characterized via <sup>1</sup>H, <sup>13</sup>C-NMR, UV, IR, and mass spectral data.
ISSN:	1422-8599