<i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide
<i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide was prepared by a reaction between tryptamine and flurbiprofen, applying <i>N</i>,<i>N’</i>-Dicyclohexylcarbodiimide, as a coupling agent. The obtained new amide has...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2021/1/M1177 |
| _version_ | 1797542817380171776 |
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| author | Stanimir Manolov Iliyan Ivanov Dimitar Bojilov |
| author_facet | Stanimir Manolov Iliyan Ivanov Dimitar Bojilov |
| author_sort | Stanimir Manolov |
| collection | DOAJ |
| description | <i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide was prepared by a reaction between tryptamine and flurbiprofen, applying <i>N</i>,<i>N’</i>-Dicyclohexylcarbodiimide, as a coupling agent. The obtained new amide has a fragment similar to <i>Brequinar</i>, a compound used in SARS-CoV-2 treatment trials. The newly synthesized compound was fully analyzed and characterized via <sup>1</sup>H, <sup>13</sup>C-NMR, UV, IR, and mass spectral data. |
| first_indexed | 2024-03-10T13:35:52Z |
| format | Article |
| id | doaj.art-751e7f9d5ea64c9d877feda13c4ba5b6 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-10T13:35:52Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-751e7f9d5ea64c9d877feda13c4ba5b62023-11-21T07:31:58ZengMDPI AGMolbank1422-85992020-12-0120211M117710.3390/M1177<i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamideStanimir Manolov0Iliyan Ivanov1Dimitar Bojilov2Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tzar Assen Str., 4000 Plovdiv, BulgariaDepartment of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tzar Assen Str., 4000 Plovdiv, BulgariaDepartment of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 24 Tzar Assen Str., 4000 Plovdiv, Bulgaria<i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide was prepared by a reaction between tryptamine and flurbiprofen, applying <i>N</i>,<i>N’</i>-Dicyclohexylcarbodiimide, as a coupling agent. The obtained new amide has a fragment similar to <i>Brequinar</i>, a compound used in SARS-CoV-2 treatment trials. The newly synthesized compound was fully analyzed and characterized via <sup>1</sup>H, <sup>13</sup>C-NMR, UV, IR, and mass spectral data.https://www.mdpi.com/1422-8599/2021/1/M1177amideflurbiprofenSARS-CoV-2tryptamine |
| spellingShingle | Stanimir Manolov Iliyan Ivanov Dimitar Bojilov <i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide Molbank amide flurbiprofen SARS-CoV-2 tryptamine |
| title | <i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide |
| title_full | <i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide |
| title_fullStr | <i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide |
| title_full_unstemmed | <i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide |
| title_short | <i>N</i>-(2-(1<i>H</i>-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide |
| title_sort | i n i 2 1 i h i indol 3 yl ethyl 2 2 fluoro 1 1 biphenyl 4 yl propanamide |
| topic | amide flurbiprofen SARS-CoV-2 tryptamine |
| url | https://www.mdpi.com/1422-8599/2021/1/M1177 |
| work_keys_str_mv | AT stanimirmanolov ini21ihiindol3ylethyl22fluoro11biphenyl4ylpropanamide AT iliyanivanov ini21ihiindol3ylethyl22fluoro11biphenyl4ylpropanamide AT dimitarbojilov ini21ihiindol3ylethyl22fluoro11biphenyl4ylpropanamide |