Comparing the effectiveness of propranolol versus atenolol in inducing clinical clearance in the treatment of infantile haemangioma: A randomised controlled trial
Background: Despite the excellent clinical efficacy of oral propranolol in the management of infantile haemangiomas (IHs), there is a need to further evaluate other beta blockers that may be equally efficacious but result in lesser adverse effects. We compared the efficacy and short-term safety of a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Dermatology |
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| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=2;spage=148;epage=155;aulast=Ashraf |
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| author | Raihan Ashraf Rahul Mahajan Muneer A Malik Sanjeev Handa Anindita Sinha Dipankar De Naresh Sachdeva |
| author_facet | Raihan Ashraf Rahul Mahajan Muneer A Malik Sanjeev Handa Anindita Sinha Dipankar De Naresh Sachdeva |
| author_sort | Raihan Ashraf |
| collection | DOAJ |
| description | Background: Despite the excellent clinical efficacy of oral propranolol in the management of infantile haemangiomas (IHs), there is a need to further evaluate other beta blockers that may be equally efficacious but result in lesser adverse effects. We compared the efficacy and short-term safety of atenolol, a hydrophilic cardio-selective beta blocker, with propranolol, in the treatment of IHs. Materials and Methods: Sixty patients with complicated and/or cosmetically significant IHs were randomised into two groups, oral propranolol group (2 mg/kg/day) and the oral atenolol (1 mg/kg/day) group, respectively, for 9 months. Patients were assessed clinically, by the use of Doppler ultrasonography (USG) and measurement of serum hypoxia-inducible factor 1 alpha (HIF-1α). Results: Twenty-two of 30 patients achieved complete clearance in the propranolol group (0.73; 95% CI = 0.54 to 0.87) compared with 13 of 25 patients in the atenolol group (0.52; 95% CI = 0.31 to 0.72). The mean time to achieve Physician Global Assessment Score 5 (PGA5) (25.00 ± 8.87 weeks) was significantly lesser in the propranolol group versus the atenolol group (31.69 ± 7.01 weeks; log-rank = 0.04). The two groups were comparable in terms of adverse effect profile, degree of volume reduction in USG and reduction in HIF-1α levels. Conclusions: Propranolol (2 mg/kg/day) is better than atenolol (1 mg/kg/day) in inducing complete clinical clearance of IH although the results need to be reproduced in larger studies.
ClinicalTrials.gov Identifier: NCT03237637 |
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| format | Article |
| id | doaj.art-751ea698a5aa4484b2ec725f886e93db |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-03-13T10:37:06Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-751ea698a5aa4484b2ec725f886e93db2023-05-18T05:46:28ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112023-01-0168214815510.4103/ijd.ijd_867_22Comparing the effectiveness of propranolol versus atenolol in inducing clinical clearance in the treatment of infantile haemangioma: A randomised controlled trialRaihan AshrafRahul MahajanMuneer A MalikSanjeev HandaAnindita SinhaDipankar DeNaresh SachdevaBackground: Despite the excellent clinical efficacy of oral propranolol in the management of infantile haemangiomas (IHs), there is a need to further evaluate other beta blockers that may be equally efficacious but result in lesser adverse effects. We compared the efficacy and short-term safety of atenolol, a hydrophilic cardio-selective beta blocker, with propranolol, in the treatment of IHs. Materials and Methods: Sixty patients with complicated and/or cosmetically significant IHs were randomised into two groups, oral propranolol group (2 mg/kg/day) and the oral atenolol (1 mg/kg/day) group, respectively, for 9 months. Patients were assessed clinically, by the use of Doppler ultrasonography (USG) and measurement of serum hypoxia-inducible factor 1 alpha (HIF-1α). Results: Twenty-two of 30 patients achieved complete clearance in the propranolol group (0.73; 95% CI = 0.54 to 0.87) compared with 13 of 25 patients in the atenolol group (0.52; 95% CI = 0.31 to 0.72). The mean time to achieve Physician Global Assessment Score 5 (PGA5) (25.00 ± 8.87 weeks) was significantly lesser in the propranolol group versus the atenolol group (31.69 ± 7.01 weeks; log-rank = 0.04). The two groups were comparable in terms of adverse effect profile, degree of volume reduction in USG and reduction in HIF-1α levels. Conclusions: Propranolol (2 mg/kg/day) is better than atenolol (1 mg/kg/day) in inducing complete clinical clearance of IH although the results need to be reproduced in larger studies. ClinicalTrials.gov Identifier: NCT03237637http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=2;spage=148;epage=155;aulast=Ashrafatenololinfantile haemangiomapropranolol |
| spellingShingle | Raihan Ashraf Rahul Mahajan Muneer A Malik Sanjeev Handa Anindita Sinha Dipankar De Naresh Sachdeva Comparing the effectiveness of propranolol versus atenolol in inducing clinical clearance in the treatment of infantile haemangioma: A randomised controlled trial Indian Journal of Dermatology atenolol infantile haemangioma propranolol |
| title | Comparing the effectiveness of propranolol versus atenolol in inducing clinical clearance in the treatment of infantile haemangioma: A randomised controlled trial |
| title_full | Comparing the effectiveness of propranolol versus atenolol in inducing clinical clearance in the treatment of infantile haemangioma: A randomised controlled trial |
| title_fullStr | Comparing the effectiveness of propranolol versus atenolol in inducing clinical clearance in the treatment of infantile haemangioma: A randomised controlled trial |
| title_full_unstemmed | Comparing the effectiveness of propranolol versus atenolol in inducing clinical clearance in the treatment of infantile haemangioma: A randomised controlled trial |
| title_short | Comparing the effectiveness of propranolol versus atenolol in inducing clinical clearance in the treatment of infantile haemangioma: A randomised controlled trial |
| title_sort | comparing the effectiveness of propranolol versus atenolol in inducing clinical clearance in the treatment of infantile haemangioma a randomised controlled trial |
| topic | atenolol infantile haemangioma propranolol |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=2;spage=148;epage=155;aulast=Ashraf |
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