Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-βH1 cells

Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-βH1 cells

Background: Enhanced IAPP production may contribute to islet amyloid formation in type 2 diabetes. The objective of this study was to determine the effects of the saturated fatty acid palmitate on IAPP levels in human β-cells. Methods: EndoC-βH1 cells and human islets were cultured in the presence o...

Full description

Bibliographic Details
Main Authors: Camilla Krizhanovskii, Rikard G. Fred, Marie E. Oskarsson, Gunilla T. Westermark, Nils Welsh
Format: Article
Language:English
Published: Upsala Medical Society 2017-07-01
Series:Upsala Journal of Medical Sciences
Subjects:
Amyloid
fatty acids
insulin
islet amyloid polypeptide (IAPP)
palmitate
Online Access:http://dx.doi.org/10.1080/03009734.2017.1368745

Similar Items

Similar Items