Nanomaterial Delivery Systems for mRNA Vaccines
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as adjuvants and in vaccine reactogenicity. We pr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/9/1/65 |
| _version_ | 1797409543049707520 |
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| author | Michael D. Buschmann Manuel J. Carrasco Suman Alishetty Mikell Paige Mohamad Gabriel Alameh Drew Weissman |
| author_facet | Michael D. Buschmann Manuel J. Carrasco Suman Alishetty Mikell Paige Mohamad Gabriel Alameh Drew Weissman |
| author_sort | Michael D. Buschmann |
| collection | DOAJ |
| description | The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as adjuvants and in vaccine reactogenicity. We present an overview of mRNA delivery systems and then focus on the lipid nanoparticles used in the current SARS-CoV-2 vaccine clinical trials. The review concludes with an analysis of the determinants of the performance of lipid nanoparticles in mRNA vaccines. |
| first_indexed | 2024-03-09T04:17:04Z |
| format | Article |
| id | doaj.art-7520c01c5127460eac7a71be1bad4007 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T04:17:04Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-7520c01c5127460eac7a71be1bad40072023-12-03T13:52:48ZengMDPI AGVaccines2076-393X2021-01-01916510.3390/vaccines9010065Nanomaterial Delivery Systems for mRNA VaccinesMichael D. Buschmann0Manuel J. Carrasco1Suman Alishetty2Mikell Paige3Mohamad Gabriel Alameh4Drew Weissman5Department of Bioengineering, George Mason University, 4400 University Drive, MS 1J7, Fairfax, VA 22030, USADepartment of Bioengineering, George Mason University, 4400 University Drive, MS 1J7, Fairfax, VA 22030, USADepartment of Bioengineering, George Mason University, 4400 University Drive, MS 1J7, Fairfax, VA 22030, USADepartment of Chemistry & Biochemistry, George Mason University, 4400 University Drive, Fairfax, VA 22030, USAPerelman School of Medicine, University of Pennsylvania, 130 Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA 19104, USAPerelman School of Medicine, University of Pennsylvania, 410B Hill Pavilion, 380 S. University Ave, Philadelphia, PA 19104, USAThe recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as adjuvants and in vaccine reactogenicity. We present an overview of mRNA delivery systems and then focus on the lipid nanoparticles used in the current SARS-CoV-2 vaccine clinical trials. The review concludes with an analysis of the determinants of the performance of lipid nanoparticles in mRNA vaccines.https://www.mdpi.com/2076-393X/9/1/65mRNAlipid nanoparticleionizable lipidvaccineSARS-CoV-2 |
| spellingShingle | Michael D. Buschmann Manuel J. Carrasco Suman Alishetty Mikell Paige Mohamad Gabriel Alameh Drew Weissman Nanomaterial Delivery Systems for mRNA Vaccines Vaccines mRNA lipid nanoparticle ionizable lipid vaccine SARS-CoV-2 |
| title | Nanomaterial Delivery Systems for mRNA Vaccines |
| title_full | Nanomaterial Delivery Systems for mRNA Vaccines |
| title_fullStr | Nanomaterial Delivery Systems for mRNA Vaccines |
| title_full_unstemmed | Nanomaterial Delivery Systems for mRNA Vaccines |
| title_short | Nanomaterial Delivery Systems for mRNA Vaccines |
| title_sort | nanomaterial delivery systems for mrna vaccines |
| topic | mRNA lipid nanoparticle ionizable lipid vaccine SARS-CoV-2 |
| url | https://www.mdpi.com/2076-393X/9/1/65 |
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