Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study
Abstract Introduction High altitude (HA) exposure leads to cognitive impairment while the underlying mechanism is still unclear. Brain functional network is crucial for advanced functions, and its alteration is implicated in cognitive decline in multiple diseases. The aim of current study was to inv...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1656 |
| _version_ | 1818299806127226880 |
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| author | Zhenlong Xin Xiaoming Chen Qian Zhang Jiye Wang Yibin Xi Jian Liu Baojuan Li Xiaoru Dong Yiwen Lin Wenbin Zhang Jingyuan Chen Wenjing Luo |
| author_facet | Zhenlong Xin Xiaoming Chen Qian Zhang Jiye Wang Yibin Xi Jian Liu Baojuan Li Xiaoru Dong Yiwen Lin Wenbin Zhang Jingyuan Chen Wenjing Luo |
| author_sort | Zhenlong Xin |
| collection | DOAJ |
| description | Abstract Introduction High altitude (HA) exposure leads to cognitive impairment while the underlying mechanism is still unclear. Brain functional network is crucial for advanced functions, and its alteration is implicated in cognitive decline in multiple diseases. The aim of current study was to investigate the topological changes in HA‐exposed brain functional network. Methods Based on Shaanxi‐Tibet immigrant cohort, neuropsychological tests and resting‐state functional MRI were applied to evaluate the participants' cognitive function and functional connection (FC) changes, respectively. GRETNA toolbox was used to construct the brain functional network. The gray matter was parcellated into 116 anatomically defined regions according to Automated Anatomical Labeling atlas. Subsequently, the mean time series for each of the 116 regions were extracted and computed for Pearson's correlation coefficients. The relation matrix was further processed and seen as brain functional network. Correlation between functional network changes and neuropsychological results was also examined. Results The cognitive performance was impaired by HA exposure as indicated by neuropsychological test. HA exposure led to alterations of degree centrality and nodal efficiency in multiple brain regions. Moreover, two subnetworks were extracted in which the FCs significantly decreased after exposure. In addition, the alterations in FCs within above two subnetworks were significantly correlated with changes of memory and reaction time. Conclusions Our results suggest that HA exposure modulates the topological property of functional network and FCs of some important regions, which may impair the attention, perception, memory, motion ignition, and modulation processes, finally decreasing cognitive performance in neuropsychological tests. |
| first_indexed | 2024-12-13T04:57:04Z |
| format | Article |
| id | doaj.art-75228624fe3b4c55aec08c30aedb0a2d |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-13T04:57:04Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-75228624fe3b4c55aec08c30aedb0a2d2022-12-21T23:58:53ZengWileyBrain and Behavior2162-32792020-10-011010n/an/a10.1002/brb3.1656Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel studyZhenlong Xin0Xiaoming Chen1Qian Zhang2Jiye Wang3Yibin Xi4Jian Liu5Baojuan Li6Xiaoru Dong7Yiwen Lin8Wenbin Zhang9Jingyuan Chen10Wenjing Luo11Department of Occupational and Environmental Health the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Air Force Medical University Xi'an ChinaDepartment of Occupational and Environmental Health the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Air Force Medical University Xi'an ChinaDepartment of Occupational and Environmental Health the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Air Force Medical University Xi'an ChinaDepartment of Occupational and Environmental Health the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Air Force Medical University Xi'an ChinaDepartment of Radiology Xijing Hospital Air Force Medical University Xi'an ChinaNetwork Center Air Force Medical University Xi'an ChinaSchool of Biomedical Engineering Air Force Medical University Xi'an ChinaDepartment of Occupational and Environmental Health the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Air Force Medical University Xi'an ChinaSchool of Basic Medical Science Peking University Beijing ChinaDepartment of Occupational and Environmental Health the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Air Force Medical University Xi'an ChinaDepartment of Occupational and Environmental Health the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Air Force Medical University Xi'an ChinaDepartment of Occupational and Environmental Health the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Air Force Medical University Xi'an ChinaAbstract Introduction High altitude (HA) exposure leads to cognitive impairment while the underlying mechanism is still unclear. Brain functional network is crucial for advanced functions, and its alteration is implicated in cognitive decline in multiple diseases. The aim of current study was to investigate the topological changes in HA‐exposed brain functional network. Methods Based on Shaanxi‐Tibet immigrant cohort, neuropsychological tests and resting‐state functional MRI were applied to evaluate the participants' cognitive function and functional connection (FC) changes, respectively. GRETNA toolbox was used to construct the brain functional network. The gray matter was parcellated into 116 anatomically defined regions according to Automated Anatomical Labeling atlas. Subsequently, the mean time series for each of the 116 regions were extracted and computed for Pearson's correlation coefficients. The relation matrix was further processed and seen as brain functional network. Correlation between functional network changes and neuropsychological results was also examined. Results The cognitive performance was impaired by HA exposure as indicated by neuropsychological test. HA exposure led to alterations of degree centrality and nodal efficiency in multiple brain regions. Moreover, two subnetworks were extracted in which the FCs significantly decreased after exposure. In addition, the alterations in FCs within above two subnetworks were significantly correlated with changes of memory and reaction time. Conclusions Our results suggest that HA exposure modulates the topological property of functional network and FCs of some important regions, which may impair the attention, perception, memory, motion ignition, and modulation processes, finally decreasing cognitive performance in neuropsychological tests.https://doi.org/10.1002/brb3.1656brain functional networkcognitionhigh altituderesting‐state functional MRItopological properties |
| spellingShingle | Zhenlong Xin Xiaoming Chen Qian Zhang Jiye Wang Yibin Xi Jian Liu Baojuan Li Xiaoru Dong Yiwen Lin Wenbin Zhang Jingyuan Chen Wenjing Luo Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study Brain and Behavior brain functional network cognition high altitude resting‐state functional MRI topological properties |
| title | Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study |
| title_full | Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study |
| title_fullStr | Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study |
| title_full_unstemmed | Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study |
| title_short | Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study |
| title_sort | alteration in topological properties of brain functional network after 2 year high altitude exposure a panel study |
| topic | brain functional network cognition high altitude resting‐state functional MRI topological properties |
| url | https://doi.org/10.1002/brb3.1656 |
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