A Role for Tetracycline Selection in Recent Evolution of Agriculture-Associated <italic toggle="yes">Clostridium difficile</italic> PCR Ribotype 078

A Role for Tetracycline Selection in Recent Evolution of Agriculture-Associated <italic toggle="yes">Clostridium difficile</italic> PCR Ribotype 078

ABSTRACT The increasing clinical importance of human infections (frequently severe) caused by Clostridium difficile PCR ribotype 078 (RT078) was first reported in 2008. The severity of symptoms (mortality of ≤30%) and the higher proportion of infections among community and younger patients raised co...

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Bibliographic Details
Main Authors: Kate E. Dingle, Xavier Didelot, T. Phuong Quan, David W. Eyre, Nicole Stoesser, Charis A. Marwick, John Coia, Derek Brown, Sarah Buchanan, Umer Z. Ijaz, Cosmika Goswami, Gill Douce, Warren N. Fawley, Mark H. Wilcox, Timothy E. A. Peto, A. Sarah Walker, Derrick W. Crook
Format: Article
Language:English
Published: American Society for Microbiology 2019-04-01
Series:mBio
Subjects:
Clostridium difficile
tetracycline resistance
whole-genome sequencing
phylogenetic analysis
emerging pathogen
PCR ribotype 078
Online Access:https://journals.asm.org/doi/10.1128/mBio.02790-18

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