Cisplatin induced Mitochondrial DNA damage in dorsal root ganglion neurons

Cisplatin induced Mitochondrial DNA damage in dorsal root ganglion neurons

Cisplatin is a platinum-based chemotherapeutic agent that induces peripheral neuropathy in 30% of patients. Peripheral neuropathy is the dose limiting side effect, which has no preventative therapy. We have previously shown that cisplatin induces apoptosis in dorsal root ganglion (DRG) sensory neuro...

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Bibliographic Details
Main Authors: Jewel L. Podratz, Andrew M. Knight, Lauren E. Ta, Nathan P. Staff, Jennifer M. Gass, Konstantin Genelin, Alexander Schlattau, Liselle Lathroum, Anthony J. Windebank
Format: Article
Language:English
Published: Elsevier 2011-03-01
Series:Neurobiology of Disease
Subjects:
Chemotherapy: Neuropathy
DRG neurons
Cisplatin
Mitochondria: DNA and DNA damage
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611000392X

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