Immunogenicity and tolerance induction in vascularized composite allotransplantation
Vascularized composite allotransplantation (VCA) is the transplantation of multiple tissues such as skin, muscle, bone, nerve, and vessels, as a functional unit (i.e., hand or face) to patients suffering from major tissue trauma and functional deficits. Though the surgical feasibility has been optim...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Transplantation |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2024.1350546/full |
| _version_ | 1797315986348572672 |
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| author | Jiahui (Angela) Sun Jiahui (Angela) Sun Aisha Adil Aisha Adil Felor Biniazan Siba Haykal Siba Haykal Siba Haykal |
| author_facet | Jiahui (Angela) Sun Jiahui (Angela) Sun Aisha Adil Aisha Adil Felor Biniazan Siba Haykal Siba Haykal Siba Haykal |
| author_sort | Jiahui (Angela) Sun |
| collection | DOAJ |
| description | Vascularized composite allotransplantation (VCA) is the transplantation of multiple tissues such as skin, muscle, bone, nerve, and vessels, as a functional unit (i.e., hand or face) to patients suffering from major tissue trauma and functional deficits. Though the surgical feasibility has been optimized, issues regarding graft rejection remains. VCA rejection involves a diverse population of cells but is primarily driven by both donor and recipient lymphocytes, antigen-presenting cells, macrophages, and other immune as well as donor-derived cells. In addition, it is commonly understood that different tissues within VCA, such as the skin, elicits a stronger rejection response. Currently, VCA recipients are required to follow potent and lifelong immunosuppressing regimens to maximize graft survival. This puts patients at risk for malignancies, opportunistic infections, and cancers, thereby posing a need for less perilous methods of inducing graft tolerance. This review will provide an overview of cell populations and mechanisms, specific tissue involved in VCA rejection, as well as an updated scope of current methods of tolerance induction. |
| first_indexed | 2024-03-08T03:11:47Z |
| format | Article |
| id | doaj.art-752b98a9dcca4c67a24f966f4c70635a |
| institution | Directory Open Access Journal |
| issn | 2813-2440 |
| language | English |
| last_indexed | 2024-03-08T03:11:47Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj.art-752b98a9dcca4c67a24f966f4c70635a2024-02-13T04:37:03ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402024-02-01310.3389/frtra.2024.13505461350546Immunogenicity and tolerance induction in vascularized composite allotransplantationJiahui (Angela) Sun0Jiahui (Angela) Sun1Aisha Adil2Aisha Adil3Felor Biniazan4Siba Haykal5Siba Haykal6Siba Haykal7Latner Thoracic Surgery Laboratories, University Health Network, Toronto General Hospital, University of Toronto, Toronto, ON, CanadaInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaLatner Thoracic Surgery Laboratories, University Health Network, Toronto General Hospital, University of Toronto, Toronto, ON, CanadaInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaLatner Thoracic Surgery Laboratories, University Health Network, Toronto General Hospital, University of Toronto, Toronto, ON, CanadaLatner Thoracic Surgery Laboratories, University Health Network, Toronto General Hospital, University of Toronto, Toronto, ON, CanadaInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaDivision of Plastic & Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, ON, CanadaVascularized composite allotransplantation (VCA) is the transplantation of multiple tissues such as skin, muscle, bone, nerve, and vessels, as a functional unit (i.e., hand or face) to patients suffering from major tissue trauma and functional deficits. Though the surgical feasibility has been optimized, issues regarding graft rejection remains. VCA rejection involves a diverse population of cells but is primarily driven by both donor and recipient lymphocytes, antigen-presenting cells, macrophages, and other immune as well as donor-derived cells. In addition, it is commonly understood that different tissues within VCA, such as the skin, elicits a stronger rejection response. Currently, VCA recipients are required to follow potent and lifelong immunosuppressing regimens to maximize graft survival. This puts patients at risk for malignancies, opportunistic infections, and cancers, thereby posing a need for less perilous methods of inducing graft tolerance. This review will provide an overview of cell populations and mechanisms, specific tissue involved in VCA rejection, as well as an updated scope of current methods of tolerance induction.https://www.frontiersin.org/articles/10.3389/frtra.2024.1350546/fullvascularized composite allograft (VCA)immunogenicitygraft rejectiontolerance inductiontissue engineering |
| spellingShingle | Jiahui (Angela) Sun Jiahui (Angela) Sun Aisha Adil Aisha Adil Felor Biniazan Siba Haykal Siba Haykal Siba Haykal Immunogenicity and tolerance induction in vascularized composite allotransplantation Frontiers in Transplantation vascularized composite allograft (VCA) immunogenicity graft rejection tolerance induction tissue engineering |
| title | Immunogenicity and tolerance induction in vascularized composite allotransplantation |
| title_full | Immunogenicity and tolerance induction in vascularized composite allotransplantation |
| title_fullStr | Immunogenicity and tolerance induction in vascularized composite allotransplantation |
| title_full_unstemmed | Immunogenicity and tolerance induction in vascularized composite allotransplantation |
| title_short | Immunogenicity and tolerance induction in vascularized composite allotransplantation |
| title_sort | immunogenicity and tolerance induction in vascularized composite allotransplantation |
| topic | vascularized composite allograft (VCA) immunogenicity graft rejection tolerance induction tissue engineering |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2024.1350546/full |
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