Minimal-moderate variation of human oral virome and microbiome in IgA deficiency
Abstract Immunoglobulin A (IgA) is the dominant antibody found in our mucosal secretions and has long been recognized to play an important role in protecting our epithelium from pathogens. Recently, IgA has been shown to be involved in gut homeostatic regulation by ‘recognizing’ and shaping our comm...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-94507-8 |
| _version_ | 1818430448957652992 |
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| author | Maria José de la Cruz Peña Luis Ignacio Gonzalez-Granado Inmaculada Garcia-Heredia Lucia Maestre Carballa Manuel Martinez-Garcia |
| author_facet | Maria José de la Cruz Peña Luis Ignacio Gonzalez-Granado Inmaculada Garcia-Heredia Lucia Maestre Carballa Manuel Martinez-Garcia |
| author_sort | Maria José de la Cruz Peña |
| collection | DOAJ |
| description | Abstract Immunoglobulin A (IgA) is the dominant antibody found in our mucosal secretions and has long been recognized to play an important role in protecting our epithelium from pathogens. Recently, IgA has been shown to be involved in gut homeostatic regulation by ‘recognizing’ and shaping our commensal microbes. Paradoxically, yet selective IgA-deficiency is often described as asymptomatic and there is a paucity of studies only focused on the mice and human gut microbiome context fully ignoring other niches of our body and our commensal viruses. Here, we used as a model the human oral cavity and employed a holistic view and studied the impact of IgA deficiency and also common variable IgA and IgM immunodeficiencies (CVID), on both the human virome and microbiome. Unexpectedly, metagenomic and experimental data in human IgA deficiency and CVID indicate minimal-moderate changes in microbiome and virome composition compared to healthy control group and point out to a rather functional, resilient oral commensal viruses and microbes. However, a significant depletion (two fold) of bacterial cells (p-value < 0.01) and viruses was observed in IgA-deficiency. Our results demonstrate that, within the limits of our cohort, IgA role is not critical for maintaining a rather functional salivary microbiome and suggest that IgA is not a major influence on the composition of abundant commensal microbes. |
| first_indexed | 2024-12-14T15:33:35Z |
| format | Article |
| id | doaj.art-752c691682d943b5b1978b536a1e4326 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T15:33:35Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-752c691682d943b5b1978b536a1e43262022-12-21T22:55:47ZengNature PortfolioScientific Reports2045-23222021-07-011111710.1038/s41598-021-94507-8Minimal-moderate variation of human oral virome and microbiome in IgA deficiencyMaria José de la Cruz Peña0Luis Ignacio Gonzalez-Granado1Inmaculada Garcia-Heredia2Lucia Maestre Carballa3Manuel Martinez-Garcia4Department of Physiology, Genetics, and Microbiology, University of AlicantePrimary Immunodeficiencies Unit, Pediatrics, Hospital 12 Octubre, Instituto de Investigación Hospital 12 octubre (imas12)Department of Physiology, Genetics, and Microbiology, University of AlicanteDepartment of Physiology, Genetics, and Microbiology, University of AlicanteDepartment of Physiology, Genetics, and Microbiology, University of AlicanteAbstract Immunoglobulin A (IgA) is the dominant antibody found in our mucosal secretions and has long been recognized to play an important role in protecting our epithelium from pathogens. Recently, IgA has been shown to be involved in gut homeostatic regulation by ‘recognizing’ and shaping our commensal microbes. Paradoxically, yet selective IgA-deficiency is often described as asymptomatic and there is a paucity of studies only focused on the mice and human gut microbiome context fully ignoring other niches of our body and our commensal viruses. Here, we used as a model the human oral cavity and employed a holistic view and studied the impact of IgA deficiency and also common variable IgA and IgM immunodeficiencies (CVID), on both the human virome and microbiome. Unexpectedly, metagenomic and experimental data in human IgA deficiency and CVID indicate minimal-moderate changes in microbiome and virome composition compared to healthy control group and point out to a rather functional, resilient oral commensal viruses and microbes. However, a significant depletion (two fold) of bacterial cells (p-value < 0.01) and viruses was observed in IgA-deficiency. Our results demonstrate that, within the limits of our cohort, IgA role is not critical for maintaining a rather functional salivary microbiome and suggest that IgA is not a major influence on the composition of abundant commensal microbes.https://doi.org/10.1038/s41598-021-94507-8 |
| spellingShingle | Maria José de la Cruz Peña Luis Ignacio Gonzalez-Granado Inmaculada Garcia-Heredia Lucia Maestre Carballa Manuel Martinez-Garcia Minimal-moderate variation of human oral virome and microbiome in IgA deficiency Scientific Reports |
| title | Minimal-moderate variation of human oral virome and microbiome in IgA deficiency |
| title_full | Minimal-moderate variation of human oral virome and microbiome in IgA deficiency |
| title_fullStr | Minimal-moderate variation of human oral virome and microbiome in IgA deficiency |
| title_full_unstemmed | Minimal-moderate variation of human oral virome and microbiome in IgA deficiency |
| title_short | Minimal-moderate variation of human oral virome and microbiome in IgA deficiency |
| title_sort | minimal moderate variation of human oral virome and microbiome in iga deficiency |
| url | https://doi.org/10.1038/s41598-021-94507-8 |
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