Proteomics analysis of chronic skin injuries caused by mustard gas
Abstract Sulfur mustard (SM) is an alkylating and forming chemical that was widely used by Iraqi forces during the Iran–Iraq wars. One of the target organs of SM is the skin. Understanding the mechanisms involved in the pathogenesis of SM may help better identify complications and find appropriate t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Medical Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12920-022-01328-3 |
| _version_ | 1811342712919556096 |
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| author | Vahid Jamshidi B. Fatemeh Nobakht M. Gh Shahram Parvin Hasan Bagheri Mostafa Ghanei Alireza Shahriary Seyyed Masoud Davoudi Masoud Arabfard |
| author_facet | Vahid Jamshidi B. Fatemeh Nobakht M. Gh Shahram Parvin Hasan Bagheri Mostafa Ghanei Alireza Shahriary Seyyed Masoud Davoudi Masoud Arabfard |
| author_sort | Vahid Jamshidi |
| collection | DOAJ |
| description | Abstract Sulfur mustard (SM) is an alkylating and forming chemical that was widely used by Iraqi forces during the Iran–Iraq wars. One of the target organs of SM is the skin. Understanding the mechanisms involved in the pathogenesis of SM may help better identify complications and find appropriate treatments. The current study collected ten SM-exposed patients with long-term skin complications and ten healthy individuals. Proteomics experiments were performed using the high-efficiency TMT10X method to evaluate the skin protein profile, and statistical bioinformatics methods were used to identify the differentially expressed proteins. One hundred twenty-nine proteins had different expressions between the two groups. Of these 129 proteins, 94 proteins had increased expression in veterans' skins, while the remaining 35 had decreased expression. The hub genes included RPS15, ACTN1, FLNA, HP, SDHC, and RPL29, and three modules were extracted from the PPI network analysis. Skin SM exposure can lead to oxidative stress, inflammation, apoptosis, and cell proliferation. |
| first_indexed | 2024-04-13T19:16:50Z |
| format | Article |
| id | doaj.art-752ea902fc4c4a21b3ffe944060837cc |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-04-13T19:16:50Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-752ea902fc4c4a21b3ffe944060837cc2022-12-22T02:33:40ZengBMCBMC Medical Genomics1755-87942022-08-0115111210.1186/s12920-022-01328-3Proteomics analysis of chronic skin injuries caused by mustard gasVahid Jamshidi0B. Fatemeh Nobakht M. Gh1Shahram Parvin2Hasan Bagheri3Mostafa Ghanei4Alireza Shahriary5Seyyed Masoud Davoudi6Masoud Arabfard7Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical SciencesChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical SciencesChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical SciencesChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical SciencesChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical SciencesChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical SciencesChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical SciencesChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical SciencesAbstract Sulfur mustard (SM) is an alkylating and forming chemical that was widely used by Iraqi forces during the Iran–Iraq wars. One of the target organs of SM is the skin. Understanding the mechanisms involved in the pathogenesis of SM may help better identify complications and find appropriate treatments. The current study collected ten SM-exposed patients with long-term skin complications and ten healthy individuals. Proteomics experiments were performed using the high-efficiency TMT10X method to evaluate the skin protein profile, and statistical bioinformatics methods were used to identify the differentially expressed proteins. One hundred twenty-nine proteins had different expressions between the two groups. Of these 129 proteins, 94 proteins had increased expression in veterans' skins, while the remaining 35 had decreased expression. The hub genes included RPS15, ACTN1, FLNA, HP, SDHC, and RPL29, and three modules were extracted from the PPI network analysis. Skin SM exposure can lead to oxidative stress, inflammation, apoptosis, and cell proliferation.https://doi.org/10.1186/s12920-022-01328-3Proteomics analysisMustard gasChemical injuriesSystems biologyChemical agents |
| spellingShingle | Vahid Jamshidi B. Fatemeh Nobakht M. Gh Shahram Parvin Hasan Bagheri Mostafa Ghanei Alireza Shahriary Seyyed Masoud Davoudi Masoud Arabfard Proteomics analysis of chronic skin injuries caused by mustard gas BMC Medical Genomics Proteomics analysis Mustard gas Chemical injuries Systems biology Chemical agents |
| title | Proteomics analysis of chronic skin injuries caused by mustard gas |
| title_full | Proteomics analysis of chronic skin injuries caused by mustard gas |
| title_fullStr | Proteomics analysis of chronic skin injuries caused by mustard gas |
| title_full_unstemmed | Proteomics analysis of chronic skin injuries caused by mustard gas |
| title_short | Proteomics analysis of chronic skin injuries caused by mustard gas |
| title_sort | proteomics analysis of chronic skin injuries caused by mustard gas |
| topic | Proteomics analysis Mustard gas Chemical injuries Systems biology Chemical agents |
| url | https://doi.org/10.1186/s12920-022-01328-3 |
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