Enteropathy-associated T cell lymphoma as a complication of silent celiac disease
Celiac disease is an autoimmune disorder in which a genetic predisposition and the ingestion of wheat gluten triggers a deleterious immune response. This response is complex and may lead to manifestations other than enteropathyha: hepatitis, dermatitis and neuropathy. There is higher risk for neopla...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-12-01
|
| Series: | Hematology Reports |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/hr/article/view/5612 |
| _version_ | 1797936314175193088 |
|---|---|
| author | Margarida Dantas Brito Ângelo Martins Rui Henrique José Mariz |
| author_facet | Margarida Dantas Brito Ângelo Martins Rui Henrique José Mariz |
| author_sort | Margarida Dantas Brito |
| collection | DOAJ |
| description | Celiac disease is an autoimmune disorder in which a genetic predisposition and the ingestion of wheat gluten triggers a deleterious immune response. This response is complex and may lead to manifestations other than enteropathyha: hepatitis, dermatitis and neuropathy. There is higher risk for neoplasia. We observed an atypical case, corresponding to a 69-year old female presenting with complicated celiac disease. The patient was referred following the histological examination of an enterectomy specimen, which unexpectedly revealed an enteropathy-associated T cell lymphoma in a background of celiac disease. Patient’s previous medical history comprised several abdominal surgical procedures, without other prior symptoms suggestive of celiac disease. Indeed, the patient was obese and no signs of malabsortion were apparent. This case draws our attention to clinically silent celiac disease, which represents a diagnostic challenge. Thus, this should be kept in mind whenever a patient presents with abdominal relapsing complications, otherwise unexplained. |
| first_indexed | 2024-04-10T18:27:49Z |
| format | Article |
| id | doaj.art-75304767478548eb8ca179dba0576247 |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:27:49Z |
| publishDate | 2014-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-75304767478548eb8ca179dba05762472023-02-02T05:05:40ZengMDPI AGHematology Reports2038-83222038-83302014-12-016410.4081/hr.2014.56122968Enteropathy-associated T cell lymphoma as a complication of silent celiac diseaseMargarida Dantas Brito0Ângelo Martins1Rui Henrique2José Mariz3Department of Hematology, Portuguese Institute of Oncology of PortoDepartment of Hematology, Portuguese Institute of Oncology of PortoDepartment of Pathology, Portuguese Institute of Oncology of PortoDepartment of Hematology, Portuguese Institute of Oncology of PortoCeliac disease is an autoimmune disorder in which a genetic predisposition and the ingestion of wheat gluten triggers a deleterious immune response. This response is complex and may lead to manifestations other than enteropathyha: hepatitis, dermatitis and neuropathy. There is higher risk for neoplasia. We observed an atypical case, corresponding to a 69-year old female presenting with complicated celiac disease. The patient was referred following the histological examination of an enterectomy specimen, which unexpectedly revealed an enteropathy-associated T cell lymphoma in a background of celiac disease. Patient’s previous medical history comprised several abdominal surgical procedures, without other prior symptoms suggestive of celiac disease. Indeed, the patient was obese and no signs of malabsortion were apparent. This case draws our attention to clinically silent celiac disease, which represents a diagnostic challenge. Thus, this should be kept in mind whenever a patient presents with abdominal relapsing complications, otherwise unexplained.http://www.pagepress.org/journals/index.php/hr/article/view/5612lymphoma, celiac disease, elderly |
| spellingShingle | Margarida Dantas Brito Ângelo Martins Rui Henrique José Mariz Enteropathy-associated T cell lymphoma as a complication of silent celiac disease Hematology Reports lymphoma, celiac disease, elderly |
| title | Enteropathy-associated T cell lymphoma as a complication of silent celiac disease |
| title_full | Enteropathy-associated T cell lymphoma as a complication of silent celiac disease |
| title_fullStr | Enteropathy-associated T cell lymphoma as a complication of silent celiac disease |
| title_full_unstemmed | Enteropathy-associated T cell lymphoma as a complication of silent celiac disease |
| title_short | Enteropathy-associated T cell lymphoma as a complication of silent celiac disease |
| title_sort | enteropathy associated t cell lymphoma as a complication of silent celiac disease |
| topic | lymphoma, celiac disease, elderly |
| url | http://www.pagepress.org/journals/index.php/hr/article/view/5612 |
| work_keys_str_mv | AT margaridadantasbrito enteropathyassociatedtcelllymphomaasacomplicationofsilentceliacdisease AT angelomartins enteropathyassociatedtcelllymphomaasacomplicationofsilentceliacdisease AT ruihenrique enteropathyassociatedtcelllymphomaasacomplicationofsilentceliacdisease AT josemariz enteropathyassociatedtcelllymphomaasacomplicationofsilentceliacdisease |