Caesarean section defects may affect pregnancy outcomes after in vitro fertilization-embryo transfer: a retrospective study
Abstract Background Caesarean section rates are rising worldwide. One adverse effect of caesarean section reported in some studies is an increased risk of subfertility. Only a few studies have assessed the relationship between the previous mode of delivery and in vitro fertilization/intracytoplasmic...
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-021-03955-7 |
| _version_ | 1818577429055143936 |
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| author | Junrong Diao Ge Gao Yunshan Zhang Xinyan Wang Yinfeng Zhang Ying Han Aijun Du Haining Luo |
| author_facet | Junrong Diao Ge Gao Yunshan Zhang Xinyan Wang Yinfeng Zhang Ying Han Aijun Du Haining Luo |
| author_sort | Junrong Diao |
| collection | DOAJ |
| description | Abstract Background Caesarean section rates are rising worldwide. One adverse effect of caesarean section reported in some studies is an increased risk of subfertility. Only a few studies have assessed the relationship between the previous mode of delivery and in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) reproductive outcomes. In this study, we primarily investigated the impact of a history of caesarean section with or without defects on IVF/ICSI-ET outcomes compared to a vaginal delivery history. Methods This retrospective study included 834 women who had a IVF or ICSI treatment at our centre between 2015 and 2019 with a delivery history. In total, 401 women with a previous vaginal delivery (VD) were assigned to the VD group, and 433 women with a history of delivery by caesarean section were included, among whom 359 had a caesarean scar (CS) without a defect and were assigned to the CS group and 74 had a caesarean section defect (CSD) and were assigned to the CSD group. Baseline characteristics of the three groups were compared and analysed. Binary logistic regression analyses were performed to explore the association between clinical outcomes and different delivery modes. Results There were no significant differences in the live birth rate, biochemical pregnancy rate, clinical pregnancy rate, mean implantation rate or abnormal pregnancy rate between the CS and VD groups However, the live birth rate and mean implantation rate in the CSD group were significantly lower than those in the VD group (21.6 vs 36.4%, adjusted OR 0.50 [0.27–0.9]; 0.25 ± 0.39 vs 0.35 ± 0.41, adjusted OR 0.90 [0.81–0.99]). Among women aged ≤ 35 years, the subgroup analyses showed that the live birth rate, biochemical pregnancy rate, clinical pregnancy rate, and mean implantation rate in the CSD group were all significantly lower than those in the VD group (21.4 vs 45.8%, adjusted OR 0.35[0.15 ~ 0.85]; 38.1 vs 59.8%, adjusted OR 0.52[0.24–0.82]; 31.0 vs 55.6%, adjusted OR 0.43[0.19–0.92]; 0.27 ± 0.43 vs 0.43 ± 0.43, adjusted OR 0.85[0.43 ± 0.43]). For women older than 35 years, there was no statistically significant difference in any pregnancy outcome among the three groups. Conclusions This study suggested that the existence of a CS without a defect does not decrease the live birth rate after IVF or ICSI compared with a previous VD. However, the presence of a CSD in women, especially young women (age ≤ 35 years), significantly impaired the chances of subsequent pregnancy. |
| first_indexed | 2024-12-16T06:29:46Z |
| format | Article |
| id | doaj.art-7530fdb5b8e941a2926ec1fd53143541 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-16T06:29:46Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-7530fdb5b8e941a2926ec1fd531435412022-12-21T22:40:55ZengBMCBMC Pregnancy and Childbirth1471-23932021-07-0121111110.1186/s12884-021-03955-7Caesarean section defects may affect pregnancy outcomes after in vitro fertilization-embryo transfer: a retrospective studyJunrong Diao0Ge Gao1Yunshan Zhang2Xinyan Wang3Yinfeng Zhang4Ying Han5Aijun Du6Haining Luo7Center for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and GynecologyCenter for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and GynecologyCenter for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and GynecologyCenter for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and GynecologyCenter for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and GynecologyCenter for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and GynecologyCenter for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and GynecologyCenter for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and GynecologyAbstract Background Caesarean section rates are rising worldwide. One adverse effect of caesarean section reported in some studies is an increased risk of subfertility. Only a few studies have assessed the relationship between the previous mode of delivery and in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) reproductive outcomes. In this study, we primarily investigated the impact of a history of caesarean section with or without defects on IVF/ICSI-ET outcomes compared to a vaginal delivery history. Methods This retrospective study included 834 women who had a IVF or ICSI treatment at our centre between 2015 and 2019 with a delivery history. In total, 401 women with a previous vaginal delivery (VD) were assigned to the VD group, and 433 women with a history of delivery by caesarean section were included, among whom 359 had a caesarean scar (CS) without a defect and were assigned to the CS group and 74 had a caesarean section defect (CSD) and were assigned to the CSD group. Baseline characteristics of the three groups were compared and analysed. Binary logistic regression analyses were performed to explore the association between clinical outcomes and different delivery modes. Results There were no significant differences in the live birth rate, biochemical pregnancy rate, clinical pregnancy rate, mean implantation rate or abnormal pregnancy rate between the CS and VD groups However, the live birth rate and mean implantation rate in the CSD group were significantly lower than those in the VD group (21.6 vs 36.4%, adjusted OR 0.50 [0.27–0.9]; 0.25 ± 0.39 vs 0.35 ± 0.41, adjusted OR 0.90 [0.81–0.99]). Among women aged ≤ 35 years, the subgroup analyses showed that the live birth rate, biochemical pregnancy rate, clinical pregnancy rate, and mean implantation rate in the CSD group were all significantly lower than those in the VD group (21.4 vs 45.8%, adjusted OR 0.35[0.15 ~ 0.85]; 38.1 vs 59.8%, adjusted OR 0.52[0.24–0.82]; 31.0 vs 55.6%, adjusted OR 0.43[0.19–0.92]; 0.27 ± 0.43 vs 0.43 ± 0.43, adjusted OR 0.85[0.43 ± 0.43]). For women older than 35 years, there was no statistically significant difference in any pregnancy outcome among the three groups. Conclusions This study suggested that the existence of a CS without a defect does not decrease the live birth rate after IVF or ICSI compared with a previous VD. However, the presence of a CSD in women, especially young women (age ≤ 35 years), significantly impaired the chances of subsequent pregnancy.https://doi.org/10.1186/s12884-021-03955-7Caesarean section defectIn vitro fertilization-embryo transferPregnancy |
| spellingShingle | Junrong Diao Ge Gao Yunshan Zhang Xinyan Wang Yinfeng Zhang Ying Han Aijun Du Haining Luo Caesarean section defects may affect pregnancy outcomes after in vitro fertilization-embryo transfer: a retrospective study BMC Pregnancy and Childbirth Caesarean section defect In vitro fertilization-embryo transfer Pregnancy |
| title | Caesarean section defects may affect pregnancy outcomes after in vitro fertilization-embryo transfer: a retrospective study |
| title_full | Caesarean section defects may affect pregnancy outcomes after in vitro fertilization-embryo transfer: a retrospective study |
| title_fullStr | Caesarean section defects may affect pregnancy outcomes after in vitro fertilization-embryo transfer: a retrospective study |
| title_full_unstemmed | Caesarean section defects may affect pregnancy outcomes after in vitro fertilization-embryo transfer: a retrospective study |
| title_short | Caesarean section defects may affect pregnancy outcomes after in vitro fertilization-embryo transfer: a retrospective study |
| title_sort | caesarean section defects may affect pregnancy outcomes after in vitro fertilization embryo transfer a retrospective study |
| topic | Caesarean section defect In vitro fertilization-embryo transfer Pregnancy |
| url | https://doi.org/10.1186/s12884-021-03955-7 |
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