Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives
The Wnt signaling is one of the major pathways known to regulate embryonic development, tissue renewal and regeneration in multicellular organisms. Dysregulations of the pathway are a common cause of several types of cancer and other diseases, such as osteoporosis and rheumatoid arthritis. This make...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/3/589 |
| _version_ | 1827837146814218240 |
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| author | Artem Blagodatski Antonina Klimenko Lee Jia Vladimir L. Katanaev |
| author_facet | Artem Blagodatski Antonina Klimenko Lee Jia Vladimir L. Katanaev |
| author_sort | Artem Blagodatski |
| collection | DOAJ |
| description | The Wnt signaling is one of the major pathways known to regulate embryonic development, tissue renewal and regeneration in multicellular organisms. Dysregulations of the pathway are a common cause of several types of cancer and other diseases, such as osteoporosis and rheumatoid arthritis. This makes Wnt signaling an important therapeutic target. Small molecule activators and inhibitors of signaling pathways are important biomedical tools which allow one to harness signaling processes in the organism for therapeutic purposes in affordable and specific ways. Natural products are a well known source of biologically active small molecules with therapeutic potential. In this article, we provide an up-to-date overview of existing small molecule modulators of the Wnt pathway derived from natural products. In the first part of the review, we focus on Wnt pathway activators, which can be used for regenerative therapy in various tissues such as skin, bone, cartilage and the nervous system. The second part describes inhibitors of the pathway, which are desired agents for targeted therapies against different cancers. In each part, we pay specific attention to the mechanisms of action of the natural products, to the models on which they were investigated, and to the potential of different taxa to yield bioactive molecules capable of regulating the Wnt signaling. |
| first_indexed | 2024-03-12T06:38:13Z |
| format | Article |
| id | doaj.art-7533fd64dc8441fa99adbeca5c8b54d1 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:38:13Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7533fd64dc8441fa99adbeca5c8b54d12023-09-03T01:10:03ZengMDPI AGCells2073-44092020-03-019358910.3390/cells9030589cells9030589Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and PerspectivesArtem Blagodatski0Antonina Klimenko1Lee Jia2Vladimir L. Katanaev3School of Biomedicine, Far Eastern Federal University, Vladivostok 690090, RussiaSchool of Biomedicine, Far Eastern Federal University, Vladivostok 690090, RussiaInstitute of Oceanography, Minjiang University, Fuzhou 350108, ChinaSchool of Biomedicine, Far Eastern Federal University, Vladivostok 690090, RussiaThe Wnt signaling is one of the major pathways known to regulate embryonic development, tissue renewal and regeneration in multicellular organisms. Dysregulations of the pathway are a common cause of several types of cancer and other diseases, such as osteoporosis and rheumatoid arthritis. This makes Wnt signaling an important therapeutic target. Small molecule activators and inhibitors of signaling pathways are important biomedical tools which allow one to harness signaling processes in the organism for therapeutic purposes in affordable and specific ways. Natural products are a well known source of biologically active small molecules with therapeutic potential. In this article, we provide an up-to-date overview of existing small molecule modulators of the Wnt pathway derived from natural products. In the first part of the review, we focus on Wnt pathway activators, which can be used for regenerative therapy in various tissues such as skin, bone, cartilage and the nervous system. The second part describes inhibitors of the pathway, which are desired agents for targeted therapies against different cancers. In each part, we pay specific attention to the mechanisms of action of the natural products, to the models on which they were investigated, and to the potential of different taxa to yield bioactive molecules capable of regulating the Wnt signaling.https://www.mdpi.com/2073-4409/9/3/589natural productswnt signalingcancerregenerationdrug discover |
| spellingShingle | Artem Blagodatski Antonina Klimenko Lee Jia Vladimir L. Katanaev Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives Cells natural products wnt signaling cancer regeneration drug discover |
| title | Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives |
| title_full | Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives |
| title_fullStr | Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives |
| title_full_unstemmed | Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives |
| title_short | Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives |
| title_sort | small molecule wnt pathway modulators from natural sources history state of the art and perspectives |
| topic | natural products wnt signaling cancer regeneration drug discover |
| url | https://www.mdpi.com/2073-4409/9/3/589 |
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