The AMPKα1 Pathway Positively Regulates the Developmental Transition from Proliferation to Quiescence in Trypanosoma brucei

The AMPKα1 Pathway Positively Regulates the Developmental Transition from Proliferation to Quiescence in Trypanosoma brucei

During infection in mammals, the protozoan parasite Trypanosoma brucei transforms from a proliferative bloodstream form to a quiescent form that is pre-adapted to host transition. AMP analogs are known to induce quiescence and also inhibit TbTOR4. To examine the role of AMP-activated kinase (AMPK) i...

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Bibliographic Details
Main Authors: Manuel Saldivia, Gloria Ceballos-Pérez, Jean-Mathieu Bart, Miguel Navarro
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
Trypanosoma brucei
developmental differentiation
TOR
AMPK
quiescence
GSK3
ROS
trypanosome stumpy form
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312803

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