Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential
This paper aimed to develop two types of support materials with a mesoporous structure of mobile crystalline matter (known in the literature as MCM, namely MCM-41 and MCM-48) and to load them with gallic acid. Soft templating methodology was chosen for the preparation of the mesoporous structures—th...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/12/10/1648 |
| _version_ | 1797497368724111360 |
|---|---|
| author | Gabriela Petrisor Denisa Ficai Ludmila Motelica Roxana Doina Trusca Alexandra Cătălina Bîrcă Bogdan Stefan Vasile Georgeta Voicu Ovidiu Cristian Oprea Augustin Semenescu Anton Ficai Mircea Ionut Popitiu Irina Fierascu Radu Claudiu Fierascu Elena Lacramioara Radu Lilia Matei Laura Denisa Dragu Ioana Madalina Pitica Mihaela Economescu Coralia Bleotu |
| author_facet | Gabriela Petrisor Denisa Ficai Ludmila Motelica Roxana Doina Trusca Alexandra Cătălina Bîrcă Bogdan Stefan Vasile Georgeta Voicu Ovidiu Cristian Oprea Augustin Semenescu Anton Ficai Mircea Ionut Popitiu Irina Fierascu Radu Claudiu Fierascu Elena Lacramioara Radu Lilia Matei Laura Denisa Dragu Ioana Madalina Pitica Mihaela Economescu Coralia Bleotu |
| author_sort | Gabriela Petrisor |
| collection | DOAJ |
| description | This paper aimed to develop two types of support materials with a mesoporous structure of mobile crystalline matter (known in the literature as MCM, namely MCM-41 and MCM-48) and to load them with gallic acid. Soft templating methodology was chosen for the preparation of the mesoporous structures—the cylindrical micelles with certain structural characteristics being formed due to the hydrophilic and hydrophobic intermolecular forces which occur between the molecules of the surfactants (cetyltrimethylammonium bromide—CTAB) when a minimal micellar ionic concentration is reached. These mesoporous supports were loaded with gallic acid using three different types of MCM—gallic acid ratios (1:0.41; 1:0.82 and 1:1.21)—and their characterizations by FTIR, SEM, XRD, BET and drug release were performed. It is worth mentioning that the loading was carried out using a vacuum-assisted methodology: the mesoporous materials are firstly kept under vacuum at ~0.1 barr for 30 min followed by the addition of the polyphenol solutions. The concentration of the solutions was adapted such that the final volume covered the wet mesoporous support and—in this case—upon reaching normal atmospheric pressure, the solution was pushed inside the pores, and thus the polyphenols were mainly loaded inside the pores. Based on the S<sub>BET</sub> data, it can be seen that the specific surface area decreased considerably with the increasing ratio of gallic acid; the specific surface area decreased 3.07 and 4.25 times for MCM-41 and MCM-48, respectively. The sample with the highest polyphenol content was further evaluated from a biological point of view, alone or in association with amoxicillin administration. As expected, the MCM-41 and MCM-48 were not protective against infections—but, due to the loading of the gallic acid, a potentiated inhibition was recorded for the tested gram-negative bacterial strains. Moreover, it is important to mention that these systems can be efficient solutions for the recovery of the gut microbiota after exposure to antibiotics, for instance. |
| first_indexed | 2024-03-10T03:17:04Z |
| format | Article |
| id | doaj.art-75355e326cb542e98f50968cb4da7b2d |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:17:04Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-75355e326cb542e98f50968cb4da7b2d2023-11-23T12:25:59ZengMDPI AGNanomaterials2079-49912022-05-011210164810.3390/nano12101648Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial PotentialGabriela Petrisor0Denisa Ficai1Ludmila Motelica2Roxana Doina Trusca3Alexandra Cătălina Bîrcă4Bogdan Stefan Vasile5Georgeta Voicu6Ovidiu Cristian Oprea7Augustin Semenescu8Anton Ficai9Mircea Ionut Popitiu10Irina Fierascu11Radu Claudiu Fierascu12Elena Lacramioara Radu13Lilia Matei14Laura Denisa Dragu15Ioana Madalina Pitica16Mihaela Economescu17Coralia Bleotu18Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaNational Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaNational Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, RomaniaDepartment Engineering and Management for Transports, University POLITEHNICA of Bucharest, 060042 Bucharest, RomaniaScience and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, RomaniaDepartment of Vascular Surgery and Reconstructive Microsurgery, Victor Babes University of Medicine and Pharmacy, Timisoara, Piata Eftimie Murgu, Nr. 2, 300041 Timisoara, RomaniaNational Institute for Research & Development in Chemistry and Petrochemistry—ICECHIM, Splaiul Independentei 202, 060021 Bucharest, RomaniaNational Institute for Research & Development in Chemistry and Petrochemistry—ICECHIM, Splaiul Independentei 202, 060021 Bucharest, RomaniaStefan S. Nicolau Institute of Virology, Mihai Bravu 285, 030304 Bucharest, RomaniaStefan S. Nicolau Institute of Virology, Mihai Bravu 285, 030304 Bucharest, RomaniaStefan S. Nicolau Institute of Virology, Mihai Bravu 285, 030304 Bucharest, RomaniaStefan S. Nicolau Institute of Virology, Mihai Bravu 285, 030304 Bucharest, RomaniaStefan S. Nicolau Institute of Virology, Mihai Bravu 285, 030304 Bucharest, RomaniaStefan S. Nicolau Institute of Virology, Mihai Bravu 285, 030304 Bucharest, RomaniaThis paper aimed to develop two types of support materials with a mesoporous structure of mobile crystalline matter (known in the literature as MCM, namely MCM-41 and MCM-48) and to load them with gallic acid. Soft templating methodology was chosen for the preparation of the mesoporous structures—the cylindrical micelles with certain structural characteristics being formed due to the hydrophilic and hydrophobic intermolecular forces which occur between the molecules of the surfactants (cetyltrimethylammonium bromide—CTAB) when a minimal micellar ionic concentration is reached. These mesoporous supports were loaded with gallic acid using three different types of MCM—gallic acid ratios (1:0.41; 1:0.82 and 1:1.21)—and their characterizations by FTIR, SEM, XRD, BET and drug release were performed. It is worth mentioning that the loading was carried out using a vacuum-assisted methodology: the mesoporous materials are firstly kept under vacuum at ~0.1 barr for 30 min followed by the addition of the polyphenol solutions. The concentration of the solutions was adapted such that the final volume covered the wet mesoporous support and—in this case—upon reaching normal atmospheric pressure, the solution was pushed inside the pores, and thus the polyphenols were mainly loaded inside the pores. Based on the S<sub>BET</sub> data, it can be seen that the specific surface area decreased considerably with the increasing ratio of gallic acid; the specific surface area decreased 3.07 and 4.25 times for MCM-41 and MCM-48, respectively. The sample with the highest polyphenol content was further evaluated from a biological point of view, alone or in association with amoxicillin administration. As expected, the MCM-41 and MCM-48 were not protective against infections—but, due to the loading of the gallic acid, a potentiated inhibition was recorded for the tested gram-negative bacterial strains. Moreover, it is important to mention that these systems can be efficient solutions for the recovery of the gut microbiota after exposure to antibiotics, for instance.https://www.mdpi.com/2079-4991/12/10/1648mesoporous materialssoft templategallic aciddrug deliveryantimicrobialdysbiosis |
| spellingShingle | Gabriela Petrisor Denisa Ficai Ludmila Motelica Roxana Doina Trusca Alexandra Cătălina Bîrcă Bogdan Stefan Vasile Georgeta Voicu Ovidiu Cristian Oprea Augustin Semenescu Anton Ficai Mircea Ionut Popitiu Irina Fierascu Radu Claudiu Fierascu Elena Lacramioara Radu Lilia Matei Laura Denisa Dragu Ioana Madalina Pitica Mihaela Economescu Coralia Bleotu Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential Nanomaterials mesoporous materials soft template gallic acid drug delivery antimicrobial dysbiosis |
| title | Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential |
| title_full | Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential |
| title_fullStr | Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential |
| title_full_unstemmed | Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential |
| title_short | Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential |
| title_sort | mesoporous silica materials loaded with gallic acid with antimicrobial potential |
| topic | mesoporous materials soft template gallic acid drug delivery antimicrobial dysbiosis |
| url | https://www.mdpi.com/2079-4991/12/10/1648 |
| work_keys_str_mv | AT gabrielapetrisor mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT denisaficai mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT ludmilamotelica mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT roxanadoinatrusca mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT alexandracatalinabirca mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT bogdanstefanvasile mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT georgetavoicu mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT ovidiucristianoprea mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT augustinsemenescu mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT antonficai mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT mirceaionutpopitiu mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT irinafierascu mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT raduclaudiufierascu mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT elenalacramioararadu mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT liliamatei mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT lauradenisadragu mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT ioanamadalinapitica mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT mihaelaeconomescu mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential AT coraliableotu mesoporoussilicamaterialsloadedwithgallicacidwithantimicrobialpotential |