Morphofunctional state of the lungs respiratory part in normotensive and hypertensive rats after combined exposure to intermittent hypoxia and melatonin

<p><strong>Aim</strong>. The purpose of this work was to study and compare the combined effect of intermittent normobaric hypoxia (INH) and melatonin on the morphological and biochemical indices of the lungs respiratory part in Wistar and spontaneous hypertensive rats (SHR). <st...

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Main Authors: Roman Yanko, Mikhail Levashov, Elena Chaka, Sergey Safonov
Format: Article
Language:English
Published: Kazimierz Wielki University 2021-01-01
Series:Journal of Education, Health and Sport
Subjects:
Online Access:https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/32820
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author Roman Yanko
Mikhail Levashov
Elena Chaka
Sergey Safonov
author_facet Roman Yanko
Mikhail Levashov
Elena Chaka
Sergey Safonov
author_sort Roman Yanko
collection DOAJ
description <p><strong>Aim</strong>. The purpose of this work was to study and compare the combined effect of intermittent normobaric hypoxia (INH) and melatonin on the morphological and biochemical indices of the lungs respiratory part in Wistar and spontaneous hypertensive rats (SHR). <strong></strong></p><p><strong>Material and methods.</strong> The studies were conducted on 48 young male rats Wistar and SHR lines. The experimental rats were daily exposed to hypoxic gas mixture (12 % oxygen in nitrogen) in intermittent mode: 15 min deoxygenation / 15 min reoxygenation for 2 hours. Animals also received oral melatonin at a dose of 5 mg /1 kg of body weight once daily.</p><p><strong>Results</strong>. The sizes of alveolus were reduced, but their number and placement density were increased in SHR rats after a combined effect of INH and melatonin. The results showed a significant decrease of the interalveolar septum thickness and a tendency to decrease of the hydroxyproline concentration in the lung tissue of the experimental rats, regardless of their line.</p><p><strong>Conclusions</strong>. The 28-day combined effect of INH and melatonin increase the total alveolar surface area and reduce the amount of connective tissue in the lungs of experimental rats. These changes can improve the efficiency of the intrapulmonary gas exchange processes. <strong></strong></p>
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spelling doaj.art-75378c4ad9a2408ca0ab96023beb12872022-12-21T17:43:20ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062021-01-01111566810.12775/JEHS.2021.11.01.00626456Morphofunctional state of the lungs respiratory part in normotensive and hypertensive rats after combined exposure to intermittent hypoxia and melatoninRoman Yanko0Mikhail Levashov1Elena Chaka2Sergey Safonov3A. A. Bogomoletz Institute of PhysiologyA. A. Bogomoletz Institute of PhysiologyA. A. Bogomoletz Institute of PhysiologyA. A. Bogomoletz Institute of Physiology<p><strong>Aim</strong>. The purpose of this work was to study and compare the combined effect of intermittent normobaric hypoxia (INH) and melatonin on the morphological and biochemical indices of the lungs respiratory part in Wistar and spontaneous hypertensive rats (SHR). <strong></strong></p><p><strong>Material and methods.</strong> The studies were conducted on 48 young male rats Wistar and SHR lines. The experimental rats were daily exposed to hypoxic gas mixture (12 % oxygen in nitrogen) in intermittent mode: 15 min deoxygenation / 15 min reoxygenation for 2 hours. Animals also received oral melatonin at a dose of 5 mg /1 kg of body weight once daily.</p><p><strong>Results</strong>. The sizes of alveolus were reduced, but their number and placement density were increased in SHR rats after a combined effect of INH and melatonin. The results showed a significant decrease of the interalveolar septum thickness and a tendency to decrease of the hydroxyproline concentration in the lung tissue of the experimental rats, regardless of their line.</p><p><strong>Conclusions</strong>. The 28-day combined effect of INH and melatonin increase the total alveolar surface area and reduce the amount of connective tissue in the lungs of experimental rats. These changes can improve the efficiency of the intrapulmonary gas exchange processes. <strong></strong></p>https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/32820intermittent normobaric hypoxiamelatoninlungs
spellingShingle Roman Yanko
Mikhail Levashov
Elena Chaka
Sergey Safonov
Morphofunctional state of the lungs respiratory part in normotensive and hypertensive rats after combined exposure to intermittent hypoxia and melatonin
Journal of Education, Health and Sport
intermittent normobaric hypoxia
melatonin
lungs
title Morphofunctional state of the lungs respiratory part in normotensive and hypertensive rats after combined exposure to intermittent hypoxia and melatonin
title_full Morphofunctional state of the lungs respiratory part in normotensive and hypertensive rats after combined exposure to intermittent hypoxia and melatonin
title_fullStr Morphofunctional state of the lungs respiratory part in normotensive and hypertensive rats after combined exposure to intermittent hypoxia and melatonin
title_full_unstemmed Morphofunctional state of the lungs respiratory part in normotensive and hypertensive rats after combined exposure to intermittent hypoxia and melatonin
title_short Morphofunctional state of the lungs respiratory part in normotensive and hypertensive rats after combined exposure to intermittent hypoxia and melatonin
title_sort morphofunctional state of the lungs respiratory part in normotensive and hypertensive rats after combined exposure to intermittent hypoxia and melatonin
topic intermittent normobaric hypoxia
melatonin
lungs
url https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/32820
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AT mikhaillevashov morphofunctionalstateofthelungsrespiratorypartinnormotensiveandhypertensiveratsaftercombinedexposuretointermittenthypoxiaandmelatonin
AT elenachaka morphofunctionalstateofthelungsrespiratorypartinnormotensiveandhypertensiveratsaftercombinedexposuretointermittenthypoxiaandmelatonin
AT sergeysafonov morphofunctionalstateofthelungsrespiratorypartinnormotensiveandhypertensiveratsaftercombinedexposuretointermittenthypoxiaandmelatonin