Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.

Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.

Salicylaldehyde isonicotinoyl hydrazone (SIH) is a lipophilic, tridentate iron chelator with marked anti-oxidant and modest cytotoxic activity against neoplastic cells. However, it has poor stability in an aqueous environment due to the rapid hydrolysis of its hydrazone bond. In this study, we synth...

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Main Authors: Eliška Potůčková, Kateřina Hrušková, Jan Bureš, Petra Kovaříková, Iva A Špirková, Kateřina Pravdíková, Lucie Kolbabová, Tereza Hergeselová, Pavlína Hašková, Hana Jansová, Miloslav Macháček, Anna Jirkovská, Vera Richardson, Darius J R Lane, Danuta S Kalinowski, Des R Richardson, Kateřina Vávrová, Tomáš Šimůnek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4231169?pdf=render

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