Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial
Accumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analys...
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| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/7/1360 |
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| author | Verena Theiler-Schwetz Christian Trummer Martin R. Grübler Martin H. Keppel Armin Zittermann Andreas Tomaschitz Spyridon N. Karras Winfried März Stefan Pilz Stephanie Gängler |
| author_facet | Verena Theiler-Schwetz Christian Trummer Martin R. Grübler Martin H. Keppel Armin Zittermann Andreas Tomaschitz Spyridon N. Karras Winfried März Stefan Pilz Stephanie Gängler |
| author_sort | Verena Theiler-Schwetz |
| collection | DOAJ |
| description | Accumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analysis of the double-blind, randomized, placebo-controlled Styrian Vitamin D Hypertension Trial (2011–2014) with 200 hypertensive patients with 25(OH)D levels <30 ng/mL. We evaluated whether 2800 IU of vitamin D3/day or placebo (1:1) for 8 weeks affects 24-hour systolic ambulatory BP in patients with 25(OH)D concentrations <20 ng/mL, <16 ng/mL, and <12 ng/mL and whether achieved 25(OH)D concentrations were associated with BP measures. Taking into account correction for multiple testing, <i>p</i> values < 0.0026 were considered significant. No significant treatment effects on 24-hour BP were observed when different baseline 25(OH)D thresholds were used (all <i>p</i>-values > 0.30). However, there was a marginally significant trend towards an inverse association between the achieved 25(OH)D level with 24-hour systolic BP (−0.196 per ng/mL 25(OH)D, 95% CI (−0.325 to −0.067); <i>p</i> = 0.003). In conclusion, we could not document the antihypertensive effects of vitamin D in vitamin D-deficient individuals, but the association between achieved 25(OH)D concentrations and BP warrants further investigations on cardiovascular benefits of vitamin D in severe vitamin D deficiency. |
| first_indexed | 2024-03-09T11:33:35Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:33:35Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-7538e764d33b403d83253d99578b7ee62023-11-30T23:47:06ZengMDPI AGNutrients2072-66432022-03-01147136010.3390/nu14071360Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled TrialVerena Theiler-Schwetz0Christian Trummer1Martin R. Grübler2Martin H. Keppel3Armin Zittermann4Andreas Tomaschitz5Spyridon N. Karras6Winfried März7Stefan Pilz8Stephanie Gängler9Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaDepartment of Laboratory Medicine, Paracelsus Medical University Salzburg, 5020 Salzburg, AustriaClinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum Nordrhein-Westfalen (NRW), Ruhr University Bochum, 32545 Bad Oeynhausen, GermanyHealth Center Trofaiach-Gössgrabenstrasse, 8793 Trofaiach, AustriaNational Scholarship Foundation, 55535 Thessaloniki, GreeceClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, AustriaDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaCenter on Aging and Mobility, University Hospital Zurich, City Hospital Waid&Triemli and University of Zurich, 8006 Zurich, SwitzerlandAccumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analysis of the double-blind, randomized, placebo-controlled Styrian Vitamin D Hypertension Trial (2011–2014) with 200 hypertensive patients with 25(OH)D levels <30 ng/mL. We evaluated whether 2800 IU of vitamin D3/day or placebo (1:1) for 8 weeks affects 24-hour systolic ambulatory BP in patients with 25(OH)D concentrations <20 ng/mL, <16 ng/mL, and <12 ng/mL and whether achieved 25(OH)D concentrations were associated with BP measures. Taking into account correction for multiple testing, <i>p</i> values < 0.0026 were considered significant. No significant treatment effects on 24-hour BP were observed when different baseline 25(OH)D thresholds were used (all <i>p</i>-values > 0.30). However, there was a marginally significant trend towards an inverse association between the achieved 25(OH)D level with 24-hour systolic BP (−0.196 per ng/mL 25(OH)D, 95% CI (−0.325 to −0.067); <i>p</i> = 0.003). In conclusion, we could not document the antihypertensive effects of vitamin D in vitamin D-deficient individuals, but the association between achieved 25(OH)D concentrations and BP warrants further investigations on cardiovascular benefits of vitamin D in severe vitamin D deficiency.https://www.mdpi.com/2072-6643/14/7/1360blood pressurecardiovascular riskvitamin D deficiencycholecalciferol |
| spellingShingle | Verena Theiler-Schwetz Christian Trummer Martin R. Grübler Martin H. Keppel Armin Zittermann Andreas Tomaschitz Spyridon N. Karras Winfried März Stefan Pilz Stephanie Gängler Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial Nutrients blood pressure cardiovascular risk vitamin D deficiency cholecalciferol |
| title | Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
| title_full | Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
| title_fullStr | Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
| title_full_unstemmed | Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
| title_short | Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial |
| title_sort | effects of vitamin d supplementation on 24 hour blood pressure in patients with low 25 hydroxyvitamin d levels a randomized controlled trial |
| topic | blood pressure cardiovascular risk vitamin D deficiency cholecalciferol |
| url | https://www.mdpi.com/2072-6643/14/7/1360 |
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