FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma
Background Currently, ferritin heavy chain (FTH1) has been increasingly found to play a crucial role in cancer as a core regulator of ferroptosis, while its role of non-ferroptosis in head and neck squamous cell carcinoma (HNSCC) is still unclear. Methods Herein, we analyzed the expression level of...
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PeerJ Inc.
2023-11-01
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| Online Access: | https://peerj.com/articles/16493.pdf |
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| author | Qingyun Liao Jing Yang Zhaoyi Lu Qingshan Jiang Yongqian Gong Lijun Liu Hong Peng Qin Wang Xin Zhang Zhifeng Liu |
| author_facet | Qingyun Liao Jing Yang Zhaoyi Lu Qingshan Jiang Yongqian Gong Lijun Liu Hong Peng Qin Wang Xin Zhang Zhifeng Liu |
| author_sort | Qingyun Liao |
| collection | DOAJ |
| description | Background Currently, ferritin heavy chain (FTH1) has been increasingly found to play a crucial role in cancer as a core regulator of ferroptosis, while its role of non-ferroptosis in head and neck squamous cell carcinoma (HNSCC) is still unclear. Methods Herein, we analyzed the expression level of FTH1 in HNSCC using TCGA database, and FTH1 protein in HNSCC tissues and cell lines was determined by immunohistochemistry (IHC) and western blotting, respectively. Then, its prognostic value and relationship with clinical parameters were investigated in HNSCC patients. Additionally, the biological function of FTH1 in HNSCC was explored. Results The current study showed that FTH1 is significantly overexpressed in HNSCC tissues and related to poor prognosis and lymph node metastasis of HNSCC. FTH1 knockdown could suppress the metastasis and epithelial-mesenchymal transition (EMT) process of HNSCC. Conclusion Our findings indicate that FTH1 plays a critical role in the progression and metastasis of HNSCC and can serve as a promising prognostic factor and therapeutic target in HNSCC. |
| first_indexed | 2024-03-10T21:34:42Z |
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| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-10T21:34:42Z |
| publishDate | 2023-11-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-753a1257fa8b4b5e8e79415bf24f469e2023-11-19T15:05:18ZengPeerJ Inc.PeerJ2167-83592023-11-0111e1649310.7717/peerj.16493FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinomaQingyun Liao0Jing Yang1Zhaoyi Lu2Qingshan Jiang3Yongqian Gong4Lijun Liu5Hong Peng6Qin Wang7Xin Zhang8Zhifeng Liu9The First Affiliated Hospital, Department of Otolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaCancer Research Institute, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, University of South China, Hengyang, Hunan, ChinaOtolaryngology Major Disease Research, Key Laboratory of Hunan Province, Central South University, Changsha, Hunan, ChinaThe First Affiliated Hospital, Department of Otolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital, Department of Otolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital, Department of Otolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital, Department of Otolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaThe First Affiliated Hospital, Department of Otolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaOtolaryngology Major Disease Research, Key Laboratory of Hunan Province, Central South University, Changsha, Hunan, ChinaThe First Affiliated Hospital, Department of Otolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaBackground Currently, ferritin heavy chain (FTH1) has been increasingly found to play a crucial role in cancer as a core regulator of ferroptosis, while its role of non-ferroptosis in head and neck squamous cell carcinoma (HNSCC) is still unclear. Methods Herein, we analyzed the expression level of FTH1 in HNSCC using TCGA database, and FTH1 protein in HNSCC tissues and cell lines was determined by immunohistochemistry (IHC) and western blotting, respectively. Then, its prognostic value and relationship with clinical parameters were investigated in HNSCC patients. Additionally, the biological function of FTH1 in HNSCC was explored. Results The current study showed that FTH1 is significantly overexpressed in HNSCC tissues and related to poor prognosis and lymph node metastasis of HNSCC. FTH1 knockdown could suppress the metastasis and epithelial-mesenchymal transition (EMT) process of HNSCC. Conclusion Our findings indicate that FTH1 plays a critical role in the progression and metastasis of HNSCC and can serve as a promising prognostic factor and therapeutic target in HNSCC.https://peerj.com/articles/16493.pdfHNSCC (head and neck squamous cell carcinoma)FTH1 (ferritin heavy chain)PrognosisMetastasisBiomarker |
| spellingShingle | Qingyun Liao Jing Yang Zhaoyi Lu Qingshan Jiang Yongqian Gong Lijun Liu Hong Peng Qin Wang Xin Zhang Zhifeng Liu FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma PeerJ HNSCC (head and neck squamous cell carcinoma) FTH1 (ferritin heavy chain) Prognosis Metastasis Biomarker |
| title | FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma |
| title_full | FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma |
| title_fullStr | FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma |
| title_full_unstemmed | FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma |
| title_short | FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma |
| title_sort | fth1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma |
| topic | HNSCC (head and neck squamous cell carcinoma) FTH1 (ferritin heavy chain) Prognosis Metastasis Biomarker |
| url | https://peerj.com/articles/16493.pdf |
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