Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood
Abstract Background Little is known about the relationship between early life body size and occurrence of life-course multiple chronic diseases (multimorbidity). We aim to evaluate associations of birth weight, childhood body size, and their changes with the risks of chronic diseases and multimorbid...
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| Format: | Article |
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Nature Portfolio
2023-07-01
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| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-023-00335-4 |
| _version_ | 1797752623516876800 |
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| author | Yue Zhang Yaguan Zhou Yangyang Cheng Rodrigo M. Carrillo-Larco Muhammad Fawad Shu Chen Xiaolin Xu |
| author_facet | Yue Zhang Yaguan Zhou Yangyang Cheng Rodrigo M. Carrillo-Larco Muhammad Fawad Shu Chen Xiaolin Xu |
| author_sort | Yue Zhang |
| collection | DOAJ |
| description | Abstract Background Little is known about the relationship between early life body size and occurrence of life-course multiple chronic diseases (multimorbidity). We aim to evaluate associations of birth weight, childhood body size, and their changes with the risks of chronic diseases and multimorbidity. Methods This prospective cohort study included 246,495 UK Biobank participants (aged 40–69 years) who reported birth weight and childhood body size at 10 years old. Birth weight was categorized into low, normal, and high; childhood body size was reported as being thinner, average, or plumper. Multimorbidity was defined as having two or more of 38 chronic conditions retrieved from inpatient hospital data until 31 December, 2020. The Cox regression and quasi-Poisson mixed effects models were used to estimate the associations. Results We show that 57,071 (23.2%) participants develop multimorbidity. Low birth weight (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.26–1.33), high birth weight (HR 1.02, 95% CI > 1.00–1.05), thinner (HR 1.21, 95% CI 1.18–1.23) and plumper body size (HR 1.06, 95% CI 1.04–1.09) are associated with higher risks of multimorbidity. A U-shaped relationship between birth weight and multimorbidity is observed. Changing to be thinner or plumper is associated with multimorbidity and many conditions, compared to changing to be average. Conclusions Low birth weight, being thinner and changing to have a thinner body size in childhood are associated with higher risks of developing multimorbidity and many chronic conditions in adulthood. Early monitoring and maintaining a normal body size in childhood could have life-course benefits for preventing multimorbidity above and beyond individual conditions. |
| first_indexed | 2024-03-12T17:07:10Z |
| format | Article |
| id | doaj.art-753a1b67543d441ea63750cf07399631 |
| institution | Directory Open Access Journal |
| issn | 2730-664X |
| language | English |
| last_indexed | 2024-03-12T17:07:10Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Medicine |
| spelling | doaj.art-753a1b67543d441ea63750cf073996312023-08-06T11:23:19ZengNature PortfolioCommunications Medicine2730-664X2023-07-01311910.1038/s43856-023-00335-4Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthoodYue Zhang0Yaguan Zhou1Yangyang Cheng2Rodrigo M. Carrillo-Larco3Muhammad Fawad4Shu Chen5Xiaolin Xu6School of Public Health and The Second Affiliated Hospital, Zhejiang University School of MedicineSchool of Public Health and The Second Affiliated Hospital, Zhejiang University School of MedicineSchool of Public Health and The Second Affiliated Hospital, Zhejiang University School of MedicineHubert Department of Global Health, Rollins School of Public Health, Emory UniversitySchool of Public Health and The Second Affiliated Hospital, Zhejiang University School of MedicineAustralian Research Council Centre of Excellence in Population Ageing Research (CEPAR), University of New South WalesSchool of Public Health and The Second Affiliated Hospital, Zhejiang University School of MedicineAbstract Background Little is known about the relationship between early life body size and occurrence of life-course multiple chronic diseases (multimorbidity). We aim to evaluate associations of birth weight, childhood body size, and their changes with the risks of chronic diseases and multimorbidity. Methods This prospective cohort study included 246,495 UK Biobank participants (aged 40–69 years) who reported birth weight and childhood body size at 10 years old. Birth weight was categorized into low, normal, and high; childhood body size was reported as being thinner, average, or plumper. Multimorbidity was defined as having two or more of 38 chronic conditions retrieved from inpatient hospital data until 31 December, 2020. The Cox regression and quasi-Poisson mixed effects models were used to estimate the associations. Results We show that 57,071 (23.2%) participants develop multimorbidity. Low birth weight (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.26–1.33), high birth weight (HR 1.02, 95% CI > 1.00–1.05), thinner (HR 1.21, 95% CI 1.18–1.23) and plumper body size (HR 1.06, 95% CI 1.04–1.09) are associated with higher risks of multimorbidity. A U-shaped relationship between birth weight and multimorbidity is observed. Changing to be thinner or plumper is associated with multimorbidity and many conditions, compared to changing to be average. Conclusions Low birth weight, being thinner and changing to have a thinner body size in childhood are associated with higher risks of developing multimorbidity and many chronic conditions in adulthood. Early monitoring and maintaining a normal body size in childhood could have life-course benefits for preventing multimorbidity above and beyond individual conditions.https://doi.org/10.1038/s43856-023-00335-4 |
| spellingShingle | Yue Zhang Yaguan Zhou Yangyang Cheng Rodrigo M. Carrillo-Larco Muhammad Fawad Shu Chen Xiaolin Xu Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood Communications Medicine |
| title | Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood |
| title_full | Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood |
| title_fullStr | Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood |
| title_full_unstemmed | Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood |
| title_short | Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood |
| title_sort | association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood |
| url | https://doi.org/10.1038/s43856-023-00335-4 |
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