Multi‐omics integration reveals a core network involved in host defence and hyperkeratinization in psoriasis

Multi‐omics integration reveals a core network involved in host defence and hyperkeratinization in psoriasis

Abstract Objectives The precise pathogenesis of psoriasis remains incompletely explored. We aimed to better understand the underlying mechanisms of psoriasis, using a systems biology approach based on transcriptomics and microbiome profiling. Methods We collected the skin tissue biopsies and swabs i...

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Bibliographic Details
Main Authors: Jingwen Deng, Emmerik Leijten, Michel Olde Nordkamp, Guangjuan Zheng, Juliëtte Pouw, Weiyang Tao, Sarita Hartgring, Deepak Balak, Rianne Rijken, Runyue Huang, Timothy Radstake, Chuanjian Lu, Aridaman Pandit
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Clinical and Translational Medicine
Subjects:
gene network
hyperkeratinization
multi‐omics
psoriasis
Online Access:https://doi.org/10.1002/ctm2.976

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