Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial Overview
The cyclic nucleotides 3′,5′-adenosine monophosphate (cyclic AMP) signalling system underlies the control of many biological events and disease processes in man. Cyclic AMP is synthesised by adenylate cyclase (AC) enzymes in order to activate effector proteins and it is then degraded by phosphodiest...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/10/2274 |
| _version_ | 1797551287948017664 |
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| author | Stephen John Yarwood |
| author_facet | Stephen John Yarwood |
| author_sort | Stephen John Yarwood |
| collection | DOAJ |
| description | The cyclic nucleotides 3′,5′-adenosine monophosphate (cyclic AMP) signalling system underlies the control of many biological events and disease processes in man. Cyclic AMP is synthesised by adenylate cyclase (AC) enzymes in order to activate effector proteins and it is then degraded by phosphodiesterase (PDE) enzymes. Research in recent years has identified a range of cell-type-specific cyclic AMP effector proteins, including protein kinase A (PKA), exchange factor directly activated by cyclic AMP (EPAC), cyclic AMP responsive ion channels (CICs), and the Popeye domain containing (POPDC) proteins, which participate in different signalling mechanisms. In addition, recent advances have revealed new mechanisms of action for cyclic AMP signalling, including new effectors and new levels of compartmentalization into nanodomains, involving AKAP proteins and targeted adenylate cyclase and phosphodiesterase enzymes. This Special Issue contains 21 papers that highlight advances in our current understanding of the biology of compartmentlised cyclic AMP signalling. This ranges from issues of pathogenesis and associated molecular pathways, functional assessment of novel nanodomains, to the development of novel tool molecules and new techniques for imaging cyclic AMP compartmentilisation. This editorial aims to summarise these papers within the wider context of cyclic AMP signalling. |
| first_indexed | 2024-03-10T15:42:25Z |
| format | Article |
| id | doaj.art-753d52468ed14f20bd1f33660903372c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:42:25Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-753d52468ed14f20bd1f33660903372c2023-11-20T16:45:06ZengMDPI AGCells2073-44092020-10-01910227410.3390/cells9102274Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial OverviewStephen John Yarwood0Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Edinburgh Campus, Heriot-Watt University, Edinburgh EH14 4AS, UKThe cyclic nucleotides 3′,5′-adenosine monophosphate (cyclic AMP) signalling system underlies the control of many biological events and disease processes in man. Cyclic AMP is synthesised by adenylate cyclase (AC) enzymes in order to activate effector proteins and it is then degraded by phosphodiesterase (PDE) enzymes. Research in recent years has identified a range of cell-type-specific cyclic AMP effector proteins, including protein kinase A (PKA), exchange factor directly activated by cyclic AMP (EPAC), cyclic AMP responsive ion channels (CICs), and the Popeye domain containing (POPDC) proteins, which participate in different signalling mechanisms. In addition, recent advances have revealed new mechanisms of action for cyclic AMP signalling, including new effectors and new levels of compartmentalization into nanodomains, involving AKAP proteins and targeted adenylate cyclase and phosphodiesterase enzymes. This Special Issue contains 21 papers that highlight advances in our current understanding of the biology of compartmentlised cyclic AMP signalling. This ranges from issues of pathogenesis and associated molecular pathways, functional assessment of novel nanodomains, to the development of novel tool molecules and new techniques for imaging cyclic AMP compartmentilisation. This editorial aims to summarise these papers within the wider context of cyclic AMP signalling.https://www.mdpi.com/2073-4409/9/10/2274cyclic AMPEPACPKAPOPDCAKAPadenylate cyclase |
| spellingShingle | Stephen John Yarwood Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial Overview Cells cyclic AMP EPAC PKA POPDC AKAP adenylate cyclase |
| title | Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial Overview |
| title_full | Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial Overview |
| title_fullStr | Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial Overview |
| title_full_unstemmed | Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial Overview |
| title_short | Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial Overview |
| title_sort | special issue on new advances in cyclic amp signalling an editorial overview |
| topic | cyclic AMP EPAC PKA POPDC AKAP adenylate cyclase |
| url | https://www.mdpi.com/2073-4409/9/10/2274 |
| work_keys_str_mv | AT stephenjohnyarwood specialissueonnewadvancesincyclicampsignallinganeditorialoverview |