The Role of PPARs in Disease
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as ligand-activated transcription factors. They exist in three isoforms: PPARα, PPARβ/δ, and PPARγ. For all PPARs, lipids are endogenous ligands, linking them directly to metabolism. PPARs form heterodimers with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2367 |
| _version_ | 1797549677126615040 |
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| author | Nicole Wagner Kay-Dietrich Wagner |
| author_facet | Nicole Wagner Kay-Dietrich Wagner |
| author_sort | Nicole Wagner |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as ligand-activated transcription factors. They exist in three isoforms: PPARα, PPARβ/δ, and PPARγ. For all PPARs, lipids are endogenous ligands, linking them directly to metabolism. PPARs form heterodimers with retinoic X receptors, and upon ligand binding, they modulate the gene expression of downstream target genes, depending on the presence of co-repressors or co-activators. This results in a complex, cell type-specific regulation of proliferation, differentiation, and cell survival. PPARs are linked to metabolic disorders and are interesting pharmaceutical targets. PPARα and PPARγ agonists are already in clinical use for the treatment of hyperlipidemia and type 2 diabetes, respectively. More recently, PPARβ/δ activation came into focus as an interesting novel approach for the treatment of metabolic syndrome and associated cardiovascular diseases; however, this has been limited due to the highly controversial function of PPARβ/δ in cancer. This Special Issue of <i>Cells</i> brings together the most recent advances in understanding the various aspects of the action of PPARs, and it provides new insights into our understanding of PPARs, implying also the latest therapeutic perspectives for the utility of PPAR modulation in different disease settings. |
| first_indexed | 2024-03-10T15:17:51Z |
| format | Article |
| id | doaj.art-75444d201d9c42e4a84526469f7dab7f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:17:51Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-75444d201d9c42e4a84526469f7dab7f2023-11-20T18:47:14ZengMDPI AGCells2073-44092020-10-01911236710.3390/cells9112367The Role of PPARs in DiseaseNicole Wagner0Kay-Dietrich Wagner1Université Côte d’Azur, CNRS, INSERM, iBV, 06107 Nice, FranceUniversité Côte d’Azur, CNRS, INSERM, iBV, 06107 Nice, FrancePeroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as ligand-activated transcription factors. They exist in three isoforms: PPARα, PPARβ/δ, and PPARγ. For all PPARs, lipids are endogenous ligands, linking them directly to metabolism. PPARs form heterodimers with retinoic X receptors, and upon ligand binding, they modulate the gene expression of downstream target genes, depending on the presence of co-repressors or co-activators. This results in a complex, cell type-specific regulation of proliferation, differentiation, and cell survival. PPARs are linked to metabolic disorders and are interesting pharmaceutical targets. PPARα and PPARγ agonists are already in clinical use for the treatment of hyperlipidemia and type 2 diabetes, respectively. More recently, PPARβ/δ activation came into focus as an interesting novel approach for the treatment of metabolic syndrome and associated cardiovascular diseases; however, this has been limited due to the highly controversial function of PPARβ/δ in cancer. This Special Issue of <i>Cells</i> brings together the most recent advances in understanding the various aspects of the action of PPARs, and it provides new insights into our understanding of PPARs, implying also the latest therapeutic perspectives for the utility of PPAR modulation in different disease settings.https://www.mdpi.com/2073-4409/9/11/2367peroxisome proliferator-activated receptors (PPARs)toxicologypharmacologyligandsvascularproliferation |
| spellingShingle | Nicole Wagner Kay-Dietrich Wagner The Role of PPARs in Disease Cells peroxisome proliferator-activated receptors (PPARs) toxicology pharmacology ligands vascular proliferation |
| title | The Role of PPARs in Disease |
| title_full | The Role of PPARs in Disease |
| title_fullStr | The Role of PPARs in Disease |
| title_full_unstemmed | The Role of PPARs in Disease |
| title_short | The Role of PPARs in Disease |
| title_sort | role of ppars in disease |
| topic | peroxisome proliferator-activated receptors (PPARs) toxicology pharmacology ligands vascular proliferation |
| url | https://www.mdpi.com/2073-4409/9/11/2367 |
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