Resting blood lactate in individuals with sickle cell disease
BACKGROUND: The most common hereditary hemoglobin disorder, affecting 20 million individuals worldwide, is sickle cell disease. The vascular obstruction resulting from the sickling of cells in this disease can produce local hypoxemia, pain crises and infarction in several tissues, including the bone...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-02-01
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| Series: | Revista Brasileira de Hematologia e Hemoterapia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000100010 |
| _version_ | 1818988077515800576 |
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| author | Jefferson Petto Jaqueline Brito de Jesus Leila Monique Reis Vasques Renata Leão Silva Pinheiro Aila Mascarenhas Oliveira Kelly Aparecida Borges Spinola Wellington dos Santos Silva |
| author_facet | Jefferson Petto Jaqueline Brito de Jesus Leila Monique Reis Vasques Renata Leão Silva Pinheiro Aila Mascarenhas Oliveira Kelly Aparecida Borges Spinola Wellington dos Santos Silva |
| author_sort | Jefferson Petto |
| collection | DOAJ |
| description | BACKGROUND: The most common hereditary hemoglobin disorder, affecting 20 million individuals worldwide, is sickle cell disease. The vascular obstruction resulting from the sickling of cells in this disease can produce local hypoxemia, pain crises and infarction in several tissues, including the bones, spleen, kidneys and lungs. METHODS: The present study is characterized as a case control study, with the aim of identifying the baseline blood lactate concentration in individuals with hemoglobin SS and SC diseases. One-way ANOVA with the Tukey post-test was used to analyze the results and a p-value < 0.05 was considered significant. Calculations were made using the INSTAT statistical program. The graphs were generated using the ORING program. The study sample was composed of 31 men and women residing in the city of Santo Antônio de Jesus, Bahia, Brazil. The individuals were divided into two groups: Group GC of 16 subjects who did not present with any type of structural hemoglobinopathy; and Group GE composed of 15 individuals with ages between 2 and 35 years old, who had the SS and SC genotypes. Sample analyses were performed with 3 mL of blood during fasting. RESULTS: The baseline blood lactate concentration of the SS and SC individuals was higher than that of the control group (p<0.001) with means of 4.86 ± 0.95; 3.30 ± 0.33; 1.31 ± 0.08 IU/L for SS, SC and controls, respectively. This corroborates the initial research hypothesis. CONCLUSION: The baseline blood lactate of SS and SC individuals is 3 to 4 times higher than that of healthy subjects, probably due to the fact that these patients have a metabolic deviation to the anaerobic pathway. |
| first_indexed | 2024-12-20T19:16:51Z |
| format | Article |
| id | doaj.art-7549f38de08541bcb2ccb3da734582cb |
| institution | Directory Open Access Journal |
| issn | 1516-8484 1806-0870 |
| language | English |
| last_indexed | 2024-12-20T19:16:51Z |
| publishDate | 2011-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-7549f38de08541bcb2ccb3da734582cb2022-12-21T19:29:05ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1516-84841806-08702011-02-01331263010.5581/1516-8484.20110010Resting blood lactate in individuals with sickle cell diseaseJefferson PettoJaqueline Brito de JesusLeila Monique Reis VasquesRenata Leão Silva PinheiroAila Mascarenhas OliveiraKelly Aparecida Borges SpinolaWellington dos Santos SilvaBACKGROUND: The most common hereditary hemoglobin disorder, affecting 20 million individuals worldwide, is sickle cell disease. The vascular obstruction resulting from the sickling of cells in this disease can produce local hypoxemia, pain crises and infarction in several tissues, including the bones, spleen, kidneys and lungs. METHODS: The present study is characterized as a case control study, with the aim of identifying the baseline blood lactate concentration in individuals with hemoglobin SS and SC diseases. One-way ANOVA with the Tukey post-test was used to analyze the results and a p-value < 0.05 was considered significant. Calculations were made using the INSTAT statistical program. The graphs were generated using the ORING program. The study sample was composed of 31 men and women residing in the city of Santo Antônio de Jesus, Bahia, Brazil. The individuals were divided into two groups: Group GC of 16 subjects who did not present with any type of structural hemoglobinopathy; and Group GE composed of 15 individuals with ages between 2 and 35 years old, who had the SS and SC genotypes. Sample analyses were performed with 3 mL of blood during fasting. RESULTS: The baseline blood lactate concentration of the SS and SC individuals was higher than that of the control group (p<0.001) with means of 4.86 ± 0.95; 3.30 ± 0.33; 1.31 ± 0.08 IU/L for SS, SC and controls, respectively. This corroborates the initial research hypothesis. CONCLUSION: The baseline blood lactate of SS and SC individuals is 3 to 4 times higher than that of healthy subjects, probably due to the fact that these patients have a metabolic deviation to the anaerobic pathway.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000100010Sickle cell anemiaLactic acidPhysical exercise |
| spellingShingle | Jefferson Petto Jaqueline Brito de Jesus Leila Monique Reis Vasques Renata Leão Silva Pinheiro Aila Mascarenhas Oliveira Kelly Aparecida Borges Spinola Wellington dos Santos Silva Resting blood lactate in individuals with sickle cell disease Revista Brasileira de Hematologia e Hemoterapia Sickle cell anemia Lactic acid Physical exercise |
| title | Resting blood lactate in individuals with sickle cell disease |
| title_full | Resting blood lactate in individuals with sickle cell disease |
| title_fullStr | Resting blood lactate in individuals with sickle cell disease |
| title_full_unstemmed | Resting blood lactate in individuals with sickle cell disease |
| title_short | Resting blood lactate in individuals with sickle cell disease |
| title_sort | resting blood lactate in individuals with sickle cell disease |
| topic | Sickle cell anemia Lactic acid Physical exercise |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000100010 |
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