Therapeutic potential for targeting Annexin A1 in fibrotic diseases
Annexin A1, a well-known endogenous anti-inflammatory mediator, plays a critical role in a variety of pathological processes. Fibrosis is described by a failure of tissue regeneration and contributes to the development of many diseases. Accumulating evidence supports that Annexin A1 participates in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-11-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304222001738 |
| _version_ | 1797723763178995712 |
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| author | Zhibin Yan Xurui Cheng Tao Wang Xiangyu Hong Gang Shao Caiyun Fu |
| author_facet | Zhibin Yan Xurui Cheng Tao Wang Xiangyu Hong Gang Shao Caiyun Fu |
| author_sort | Zhibin Yan |
| collection | DOAJ |
| description | Annexin A1, a well-known endogenous anti-inflammatory mediator, plays a critical role in a variety of pathological processes. Fibrosis is described by a failure of tissue regeneration and contributes to the development of many diseases. Accumulating evidence supports that Annexin A1 participates in the progression of tissue fibrosis. However, the fundamental mechanisms by which Annexin A1 regulates fibrosis remain elusive, and even the functions of Annexin A1 in fibrotic diseases are still paradoxical. This review focuses on the roles of Annexin A1 in the development of fibrosis of lung, liver, heart, and other tissues, with emphasis on the therapy potential of Annexin A1 in fibrosis, and presents future research interests and directions in fibrotic diseases. |
| first_indexed | 2024-03-12T10:07:24Z |
| format | Article |
| id | doaj.art-754ad466eeba444298f68d4a9fc399d4 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T10:07:24Z |
| publishDate | 2022-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-754ad466eeba444298f68d4a9fc399d42023-09-02T11:08:49ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422022-11-019614931505Therapeutic potential for targeting Annexin A1 in fibrotic diseasesZhibin Yan0Xurui Cheng1Tao Wang2Xiangyu Hong3Gang Shao4Caiyun Fu5Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, PR ChinaZhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, PR ChinaZhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, PR ChinaZhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, PR ChinaDepartment of Oncology, No. 903 Hospital of PLA Joint Logistic Support Force, Xi Hu Affiliated Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310013, PR ChinaZhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, PR China; Corresponding author.Annexin A1, a well-known endogenous anti-inflammatory mediator, plays a critical role in a variety of pathological processes. Fibrosis is described by a failure of tissue regeneration and contributes to the development of many diseases. Accumulating evidence supports that Annexin A1 participates in the progression of tissue fibrosis. However, the fundamental mechanisms by which Annexin A1 regulates fibrosis remain elusive, and even the functions of Annexin A1 in fibrotic diseases are still paradoxical. This review focuses on the roles of Annexin A1 in the development of fibrosis of lung, liver, heart, and other tissues, with emphasis on the therapy potential of Annexin A1 in fibrosis, and presents future research interests and directions in fibrotic diseases.http://www.sciencedirect.com/science/article/pii/S2352304222001738Annexin A1Anti-inflammatoryFibrosisFibrotic diseasesSequence alignment |
| spellingShingle | Zhibin Yan Xurui Cheng Tao Wang Xiangyu Hong Gang Shao Caiyun Fu Therapeutic potential for targeting Annexin A1 in fibrotic diseases Genes and Diseases Annexin A1 Anti-inflammatory Fibrosis Fibrotic diseases Sequence alignment |
| title | Therapeutic potential for targeting Annexin A1 in fibrotic diseases |
| title_full | Therapeutic potential for targeting Annexin A1 in fibrotic diseases |
| title_fullStr | Therapeutic potential for targeting Annexin A1 in fibrotic diseases |
| title_full_unstemmed | Therapeutic potential for targeting Annexin A1 in fibrotic diseases |
| title_short | Therapeutic potential for targeting Annexin A1 in fibrotic diseases |
| title_sort | therapeutic potential for targeting annexin a1 in fibrotic diseases |
| topic | Annexin A1 Anti-inflammatory Fibrosis Fibrotic diseases Sequence alignment |
| url | http://www.sciencedirect.com/science/article/pii/S2352304222001738 |
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