Remodeling Serine Synthesis and Metabolism via Nanoparticles (NPs)‐Mediated CFL1 Silencing to Enhance the Sensitivity of Hepatocellular Carcinoma to Sorafenib

Remodeling Serine Synthesis and Metabolism via Nanoparticles (NPs)‐Mediated CFL1 Silencing to Enhance the Sensitivity of Hepatocellular Carcinoma to Sorafenib

Abstract Tyrosine kinase inhibitors represented by sorafenib are the first‐line treatment for hepatocellular carcinoma (HCC), but the low response rate of HCC patient has become a clinical pain‐point. Emerging evidences have revealed that metabolic reprogramming plays an important role in regulating...

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Bibliographic Details
Main Authors: Senlin Li, Lei Xu, Guo Wu, Ziqi Huang, Linzhuo Huang, Fengqian Zhang, Chunfang Wei, Qian Shen, Rong Li, Lei Zhang, Xiaoding Xu
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Advanced Science
Subjects:
cofilin 1
hepatocellular carcinoma
nanoparticles
serine synthesis and metabolism
sorafenib sensitivity
Online Access:https://doi.org/10.1002/advs.202207118

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