Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta
Two new indole alkaloids, hainanerectamines A (1) and B (2), and one new β-carboline alkaloids, hainanerectamines C (4), along with five known related alkaloids (3, 5–8), have been isolated from the Hainan marine sponge Hyrtios erecta. The structures of new compounds 1, 2 and 4 were determined by d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-06-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/12/7/3982 |
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| author | Wen-Fei He Duo-Qing Xue Li-Gong Yao Jing-Ya Li Jia Li Yue-Wei Guo |
| author_facet | Wen-Fei He Duo-Qing Xue Li-Gong Yao Jing-Ya Li Jia Li Yue-Wei Guo |
| author_sort | Wen-Fei He |
| collection | DOAJ |
| description | Two new indole alkaloids, hainanerectamines A (1) and B (2), and one new β-carboline alkaloids, hainanerectamines C (4), along with five known related alkaloids (3, 5–8), have been isolated from the Hainan marine sponge Hyrtios erecta. The structures of new compounds 1, 2 and 4 were determined by detailed analysis of their 1D and 2D NMR spectra and by comparison of their spectroscopic data with those of related model compounds. Compounds 2–4 exhibited moderate inhibitory activity against Aurora A, a member of serine/threonine kinase family involving in the regulation of cell division and a new target in cancer treatment, with IC50 values of 24.5, 13.6, and 18.6 μg/mL, respectively. |
| first_indexed | 2024-04-11T22:04:12Z |
| format | Article |
| id | doaj.art-754b3c2f036a4e3abe2cef84c4e231a9 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:04:12Z |
| publishDate | 2014-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-754b3c2f036a4e3abe2cef84c4e231a92022-12-22T04:00:47ZengMDPI AGMarine Drugs1660-33972014-06-011273982399310.3390/md12073982md12073982Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erectaWen-Fei He0Duo-Qing Xue1Li-Gong Yao2Jing-Ya Li3Jia Li4Yue-Wei Guo5School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaTwo new indole alkaloids, hainanerectamines A (1) and B (2), and one new β-carboline alkaloids, hainanerectamines C (4), along with five known related alkaloids (3, 5–8), have been isolated from the Hainan marine sponge Hyrtios erecta. The structures of new compounds 1, 2 and 4 were determined by detailed analysis of their 1D and 2D NMR spectra and by comparison of their spectroscopic data with those of related model compounds. Compounds 2–4 exhibited moderate inhibitory activity against Aurora A, a member of serine/threonine kinase family involving in the regulation of cell division and a new target in cancer treatment, with IC50 values of 24.5, 13.6, and 18.6 μg/mL, respectively.http://www.mdpi.com/1660-3397/12/7/3982spongeHyrtios erectaThorectidaehainanerectaminesindoleβ-carbolineAurora A |
| spellingShingle | Wen-Fei He Duo-Qing Xue Li-Gong Yao Jing-Ya Li Jia Li Yue-Wei Guo Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta Marine Drugs sponge Hyrtios erecta Thorectidae hainanerectamines indole β-carboline Aurora A |
| title | Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta |
| title_full | Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta |
| title_fullStr | Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta |
| title_full_unstemmed | Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta |
| title_short | Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta |
| title_sort | hainanerectamines a c alkaloids from the hainan sponge hyrtios erecta |
| topic | sponge Hyrtios erecta Thorectidae hainanerectamines indole β-carboline Aurora A |
| url | http://www.mdpi.com/1660-3397/12/7/3982 |
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