A Cloned Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine, PHV01, Protects Guinea Pigs from Lethal Marburg Virus Disease

A Cloned Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine, PHV01, Protects Guinea Pigs from Lethal Marburg Virus Disease

Marburg virus (MARV) is a negative-sense, single-stranded RNA virus that belongs to the <i>Filoviridae</i> family. Despite having caused numerous outbreaks of severe hemorrhagic fever with high case fatality rates, there are still no clinically approved therapeutics or vaccines to treat...

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Bibliographic Details
Main Authors: Wenjun Zhu, Guodong Liu, Wenguang Cao, Shihua He, Anders Leung, Ute Ströher, Michael J. Fairchild, Rick Nichols, Joseph Crowell, Joan Fusco, Logan Banadyga
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Vaccines
Subjects:
Marburg virus
VSV-MARV
vesicular stomatitis virus
vaccine
filovirus
Online Access:https://www.mdpi.com/2076-393X/10/7/1004

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