Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma
Abstract Red blood cell distribution width (RDW), which measures the range of variation of red blood cell volume, has been explored as a prognostic factor in multiple types of cancer. However, the role of RDW in mantle cell lymphoma (MCL), a rare type of non‐Hodgkin lymphoma with poor outcomes, rema...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-06-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.2155 |
| _version_ | 1828406361657966592 |
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| author | Yi Miao Xiao-Hui Zhou Jing-Jing Guo Qian Sun Ke Shi Jia‐Zhu Wu Hua‐Yuan Zhu Li Wang Lei Fan Wei Xu Jian‐Yong Li |
| author_facet | Yi Miao Xiao-Hui Zhou Jing-Jing Guo Qian Sun Ke Shi Jia‐Zhu Wu Hua‐Yuan Zhu Li Wang Lei Fan Wei Xu Jian‐Yong Li |
| author_sort | Yi Miao |
| collection | DOAJ |
| description | Abstract Red blood cell distribution width (RDW), which measures the range of variation of red blood cell volume, has been explored as a prognostic factor in multiple types of cancer. However, the role of RDW in mantle cell lymphoma (MCL), a rare type of non‐Hodgkin lymphoma with poor outcomes, remains to be determined. Therefore, we investigated the prognostic role of RDW in MCL. We found that 21 of 76 MCL patients (27.6%) had an abnormally elevated RDW (>15.7%). Abnormally elevated RDW was significantly associated with presence of B symptoms (P = 0.0020), elevated lactate dehydrogenase (LDH) (P = 0.0010), higher leukocyte count (P = 0.0345), higher simplified Mantle Cell International Prognostic Index (sMIPI) (P = 0.0194), and lower level of hemoglobin (Hb) (P < 0.0001). It was marginally associated with increased C‐reactive protein (P = 0.0862). RDW was significantly correlated with Hb level (r2 = 0.42) and LDH level (r2 = 0.19). 15.8% was determined as the best cutoff of RDW in predicting the survival outcome by the X‐tile software. Survival analysis revealed that high RDW (>15.8%) predicted shorter progression‐free survival (PFS) (hazards ratio [HR]: 3.14; P = 0.0005) and shorter overall survival (OS) (HR: 4.04; P < 0.0001). High RDW independently predicted both shorter PFS (P = 0.0493) and OS (P = 0.0118). RDW also improved the prognostic stratification based on sMIPI. In conclusion, our study identified RDW as a novel prognostic factor of clinical feasibility in the prognostication of MCL. |
| first_indexed | 2024-12-10T11:10:19Z |
| format | Article |
| id | doaj.art-754c8e2fc7fc49cab21b3d8c17b2afb0 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-10T11:10:19Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-754c8e2fc7fc49cab21b3d8c17b2afb02022-12-22T01:51:26ZengWileyCancer Medicine2045-76342019-06-01862751275810.1002/cam4.2155Association of red blood cell distribution width and outcomes in patients with mantle cell lymphomaYi Miao0Xiao-Hui Zhou1Jing-Jing Guo2Qian Sun3Ke Shi4Jia‐Zhu Wu5Hua‐Yuan Zhu6Li Wang7Lei Fan8Wei Xu9Jian‐Yong Li10Department of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaDepartment of Hematology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing ChinaAbstract Red blood cell distribution width (RDW), which measures the range of variation of red blood cell volume, has been explored as a prognostic factor in multiple types of cancer. However, the role of RDW in mantle cell lymphoma (MCL), a rare type of non‐Hodgkin lymphoma with poor outcomes, remains to be determined. Therefore, we investigated the prognostic role of RDW in MCL. We found that 21 of 76 MCL patients (27.6%) had an abnormally elevated RDW (>15.7%). Abnormally elevated RDW was significantly associated with presence of B symptoms (P = 0.0020), elevated lactate dehydrogenase (LDH) (P = 0.0010), higher leukocyte count (P = 0.0345), higher simplified Mantle Cell International Prognostic Index (sMIPI) (P = 0.0194), and lower level of hemoglobin (Hb) (P < 0.0001). It was marginally associated with increased C‐reactive protein (P = 0.0862). RDW was significantly correlated with Hb level (r2 = 0.42) and LDH level (r2 = 0.19). 15.8% was determined as the best cutoff of RDW in predicting the survival outcome by the X‐tile software. Survival analysis revealed that high RDW (>15.8%) predicted shorter progression‐free survival (PFS) (hazards ratio [HR]: 3.14; P = 0.0005) and shorter overall survival (OS) (HR: 4.04; P < 0.0001). High RDW independently predicted both shorter PFS (P = 0.0493) and OS (P = 0.0118). RDW also improved the prognostic stratification based on sMIPI. In conclusion, our study identified RDW as a novel prognostic factor of clinical feasibility in the prognostication of MCL.https://doi.org/10.1002/cam4.2155Mantle Cell International Prognostic Indexmantle cell lymphomaprognosisred blood cell distribution widthsurvival |
| spellingShingle | Yi Miao Xiao-Hui Zhou Jing-Jing Guo Qian Sun Ke Shi Jia‐Zhu Wu Hua‐Yuan Zhu Li Wang Lei Fan Wei Xu Jian‐Yong Li Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma Cancer Medicine Mantle Cell International Prognostic Index mantle cell lymphoma prognosis red blood cell distribution width survival |
| title | Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma |
| title_full | Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma |
| title_fullStr | Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma |
| title_full_unstemmed | Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma |
| title_short | Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma |
| title_sort | association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma |
| topic | Mantle Cell International Prognostic Index mantle cell lymphoma prognosis red blood cell distribution width survival |
| url | https://doi.org/10.1002/cam4.2155 |
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