Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives
Twenty-three new series of toluene-sulfonamide dipeptide derivatives were synthesized and screened for antiplasmodial and antioxidant potencies. Many of the derivatives were active against Plasmodium falciparum with IC50 ranging from 3.20 – 9.10 μM. The ability of compounds 7h, 7m and 7n (IC50 of 7....
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020318016 |
| _version_ | 1811305578988830720 |
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| author | Efeturi A. Onoabedje Akachukwu Ibezim Uchechukwu C. Okoro Sanjay Batra |
| author_facet | Efeturi A. Onoabedje Akachukwu Ibezim Uchechukwu C. Okoro Sanjay Batra |
| author_sort | Efeturi A. Onoabedje |
| collection | DOAJ |
| description | Twenty-three new series of toluene-sulfonamide dipeptide derivatives were synthesized and screened for antiplasmodial and antioxidant potencies. Many of the derivatives were active against Plasmodium falciparum with IC50 ranging from 3.20 – 9.10 μM. The ability of compounds 7h, 7m and 7n (IC50 of 7.53, 7.21 and 6.01 μg/mL respectively) to scavenge DPPH free radicals were comparable to that of ascorbic acid. Additionally, molecular docking disclosed that four compounds exhibited theoretical inhibition constant at submicromolar concentrations (Ki = 0.72, 0.75, 0.57, and 0.53 μM respectively) compare to the reference ligand (a pyrazole sulfonamide; Ki = 0.01 μM). Overall, some of the derivatives possess antimalarial property as well as the ability to inhibit oxidative stress in malaria pathophysiology; and hence, are good candidates for further antimalarial drug research. |
| first_indexed | 2024-04-13T08:28:59Z |
| format | Article |
| id | doaj.art-7550c4de3fc746aabef7b9714d970e16 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-13T08:28:59Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-7550c4de3fc746aabef7b9714d970e162022-12-22T02:54:20ZengElsevierHeliyon2405-84402020-09-0169e04958Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivativesEfeturi A. Onoabedje0Akachukwu Ibezim1Uchechukwu C. Okoro2Sanjay Batra3Department of Pure & Industrial Chemistry, Faculty of Physical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow, UP, India; Corresponding author.Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Corresponding author.Department of Pure & Industrial Chemistry, Faculty of Physical Sciences, University of Nigeria, Nsukka, Enugu State, NigeriaDivision of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow, UP, IndiaTwenty-three new series of toluene-sulfonamide dipeptide derivatives were synthesized and screened for antiplasmodial and antioxidant potencies. Many of the derivatives were active against Plasmodium falciparum with IC50 ranging from 3.20 – 9.10 μM. The ability of compounds 7h, 7m and 7n (IC50 of 7.53, 7.21 and 6.01 μg/mL respectively) to scavenge DPPH free radicals were comparable to that of ascorbic acid. Additionally, molecular docking disclosed that four compounds exhibited theoretical inhibition constant at submicromolar concentrations (Ki = 0.72, 0.75, 0.57, and 0.53 μM respectively) compare to the reference ligand (a pyrazole sulfonamide; Ki = 0.01 μM). Overall, some of the derivatives possess antimalarial property as well as the ability to inhibit oxidative stress in malaria pathophysiology; and hence, are good candidates for further antimalarial drug research.http://www.sciencedirect.com/science/article/pii/S2405844020318016Organic chemistryPharmaceutical chemistrySynthesisDipeptidesSulphonamidesAntimalarial |
| spellingShingle | Efeturi A. Onoabedje Akachukwu Ibezim Uchechukwu C. Okoro Sanjay Batra Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives Heliyon Organic chemistry Pharmaceutical chemistry Synthesis Dipeptides Sulphonamides Antimalarial |
| title | Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives |
| title_full | Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives |
| title_fullStr | Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives |
| title_full_unstemmed | Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives |
| title_short | Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives |
| title_sort | synthesis molecular docking antiplasmodial and antioxidant activities of new sulfonamido pepetide derivatives |
| topic | Organic chemistry Pharmaceutical chemistry Synthesis Dipeptides Sulphonamides Antimalarial |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020318016 |
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